Eleven patients with presenile Alzheimer type dementia (ATD) were treated with N-terminal ACTH fragments for 14 days. No change in cognitive functions was observed during the treatment. A significant increase in CSF beta-endorphin (beta-EP) levels was found, while ACTH and beta-lipoprotein remain unaffected. The possibility that ACTH and its moieties could interfere with beta-EP activities in CNS is discussed.
|Autori:||Nappi G; Facchinetti F; Martignoni E; Petraglia F; Sinforiani E; Bono G; Genazzani A|
|Titolo:||N-terminal ACTH fragments increase the CSF beta-EP content in Alzheimer type dementia.|
|Anno del prodotto:||1988|
|Appare nelle tipologie:||1.1 Articolo in rivista|