Gamma-glutamyltransferase (GGT) has been recently identified as a bone-resorbing factor. Aim of the study was to investigate the association between plasma GGT fractions levels and bone quality. Plasma GGT fractions were analysed by gel-filtration chromatography. Bone quality was established by Micro-CT parameters: the BV/TV (mineralised bone volume/total volume), and the SMI (structure model index) that describes the rod-like (low-resistant) or plate-like (high-resistant) shape of bone trabeculae. We enrolled 93 patients hospitalised for elective total hip replacement (group Arthrosis, n=46) or for proximal femoral fracture (group Fracture, n=47). Patients within the first quartile of BV/TV (Q1, osteoporotic patients, n=6) showed higher levels of b-GGT fraction [median (min-max): 3.37 (1.42–6.81)] compared to patients with normal bone density (fourth quartile Q4, n=10; 1.40 (0.83–4.36); p=0.0393]. Also according to SMI, b-GGT value was higher in the subgroup with bone fragility [Q1, n=8: 1.36 (0.43–4.36); Q4, n=8: 5.10 (1.4 –7.60); p=0.0117]. In conclusion, patients characterised fragile bone structure showed specifically higher levels of plasma b-GGT activity thus suggesting fractional GGT analysis as a possible biomarker in the diagnosis of osteoporosis

Correlation between gamma glutamyltransferase fractions and bone quality

Franzini Maria
Primo
;
Fierabracci Vanna;Marchetti Stefano;Parchi PD;Caponi Laura;Paolicchi Aldo;Scaglione M
Penultimo
;
2017

Abstract

Gamma-glutamyltransferase (GGT) has been recently identified as a bone-resorbing factor. Aim of the study was to investigate the association between plasma GGT fractions levels and bone quality. Plasma GGT fractions were analysed by gel-filtration chromatography. Bone quality was established by Micro-CT parameters: the BV/TV (mineralised bone volume/total volume), and the SMI (structure model index) that describes the rod-like (low-resistant) or plate-like (high-resistant) shape of bone trabeculae. We enrolled 93 patients hospitalised for elective total hip replacement (group Arthrosis, n=46) or for proximal femoral fracture (group Fracture, n=47). Patients within the first quartile of BV/TV (Q1, osteoporotic patients, n=6) showed higher levels of b-GGT fraction [median (min-max): 3.37 (1.42–6.81)] compared to patients with normal bone density (fourth quartile Q4, n=10; 1.40 (0.83–4.36); p=0.0393]. Also according to SMI, b-GGT value was higher in the subgroup with bone fragility [Q1, n=8: 1.36 (0.43–4.36); Q4, n=8: 5.10 (1.4 –7.60); p=0.0117]. In conclusion, patients characterised fragile bone structure showed specifically higher levels of plasma b-GGT activity thus suggesting fractional GGT analysis as a possible biomarker in the diagnosis of osteoporosis
Franzini, Maria; Nesti, Agnese; Panetta, Daniele; Fierabracci, Vanna; Marchetti, Stefano; Parchi, Pd; Caponi, Laura; Paolicchi, Aldo; Musetti, Veronica; Salvadori, P; Emdin, Michele; Pucci, Angela; Bonicoli, E; Scaglione, M; Piolanti, Nicola
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/880308
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