Following injury, compensatory mechanisms are spontaneously activated in the myocardium to maintain cardiac function but rarely prevent or reverse progression of the failing heart. Regenerative medicine and tissue engineering represent alternative approaches for the treatment of heart failure. The aim of this study was to characterize, in vitro and in vivo, the biological properties of engineered cardiac patches (CP) represented by biomimetic polyglycerol sebacate (PGS) matrix and alginate/gelatin/elastin (AGE) scaffolds. CPs were functionalized with peptides corresponding to the epitope sequences of laminin (YIGSR) and fibronectin (GRGDSP) implicated in basic cellular and structural functions.
Assessment of cardiac patches suitability for tissue engineering
Rosellini Elisabetta;
2015-01-01
Abstract
Following injury, compensatory mechanisms are spontaneously activated in the myocardium to maintain cardiac function but rarely prevent or reverse progression of the failing heart. Regenerative medicine and tissue engineering represent alternative approaches for the treatment of heart failure. The aim of this study was to characterize, in vitro and in vivo, the biological properties of engineered cardiac patches (CP) represented by biomimetic polyglycerol sebacate (PGS) matrix and alginate/gelatin/elastin (AGE) scaffolds. CPs were functionalized with peptides corresponding to the epitope sequences of laminin (YIGSR) and fibronectin (GRGDSP) implicated in basic cellular and structural functions.| File | Dimensione | Formato | |
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