Objective: Offspring of diabetic or hypertensive patients are insulin resistant at a prediabetic/prehypertensive stage. We tested the hypothesis that insulin action may be impaired in the offspring of obese nondiabetic parents. Research Methods and Procedures: Twenty-one lean offspring of nonobese subjects [(OL) 22+/-3 years of age] were matched to 23 lean offspring of obese subjects (OOb) by gender distribution, age, BMI, and waist circumference. Anthropometry, oral glucose tolerance, in vivo insulin sensitivity [by a euglycemic insulin clamp (6 pmol/min per kilogram(FFM); where FFM represents fat-free mass)], and thermogenesis (by indirect calorimetry) were measured in each subject. The study subjects were from a population of 267 nuclear families (one offspring and both his/her parents) in which there was statistically significant (chi(2)=30.2, p=0.001) concordance of BMI between parents and offspring. Results: In comparing OOb with OL, no statistically significant difference or trend toward a difference was detected in fasting plasma glucose and insulin concentrations, glucose and insulin responses to oral glucose, insulin sensitivity [metabolism value=45+/-12 (OOb) vs. 47+/-17 mumol/min per kilogram(FFM) (OL)], insulin-induced inhibition of protein and lipid oxidation, stimulation of glucose oxidation and nonoxidative glucose disposal, respiratory quotient, resting energy expenditure, and glucose-induced thermogenesis. Discussion: The metabolic similarity between lean offspring of obese parents and those of nonobese parents Suggests that insulin resistance and its correlates are not co-inherited with the predisposition to develop obesity.
|Autori:||Lazarin MACT; Bennini JR; Pereira CLC; Astiarraga BD; Ferrannini E; Muscelli E|
|Titolo:||Normal insulin sensitivity in lean offspring of obese parents|
|Anno del prodotto:||2004|
|Digital Object Identifier (DOI):||10.1038/oby.2004.71|
|Appare nelle tipologie:||1.1 Articolo in rivista|