In ALS patients, we observed a direct correlation between the ALSFRS scores and the levels of some blood analytes (CD3, CD16, CD25, IL17, CD44, sTNF-R2, VCAM, Eselectin) and an inverse correlation with others (CD19,sIL6-R, sTNF-R1, TGF, IGF, PDGF, VEGF, P-selectin);whereas, in l-MND patients, a direct correlation was found with some analytes (CD19, IFNbeta), but an inverse one with others (EPO, IL6, sTNF-R1, PDGF, E and P selectins). We found that CD3, CD4, CD8, CD16, CD25, sIL6-R, IL5 and VCAM are differentially expressed in ALS and in l-MND patients. Conclusion: Our findings are useful as prognostic and diagnostic tools for ALS/MND patients. DOI: 10.1080/21678421.2017.1371525/0014

Blood inflammatory markers in motor neuron disease patients: pattern changes over time along disease progression

Bongioanni P;Dolciotti C;Bendinelli S;Cavalli L;Pelagatti A;Carboncini M.
2017-01-01

Abstract

In ALS patients, we observed a direct correlation between the ALSFRS scores and the levels of some blood analytes (CD3, CD16, CD25, IL17, CD44, sTNF-R2, VCAM, Eselectin) and an inverse correlation with others (CD19,sIL6-R, sTNF-R1, TGF, IGF, PDGF, VEGF, P-selectin);whereas, in l-MND patients, a direct correlation was found with some analytes (CD19, IFNbeta), but an inverse one with others (EPO, IL6, sTNF-R1, PDGF, E and P selectins). We found that CD3, CD4, CD8, CD16, CD25, sIL6-R, IL5 and VCAM are differentially expressed in ALS and in l-MND patients. Conclusion: Our findings are useful as prognostic and diagnostic tools for ALS/MND patients. DOI: 10.1080/21678421.2017.1371525/0014
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/880694
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