In ALS patients, we observed a direct correlation between the ALSFRS scores and the levels of some blood analytes (CD3, CD16, CD25, IL17, CD44, sTNF-R2, VCAM, Eselectin) and an inverse correlation with others (CD19,sIL6-R, sTNF-R1, TGF, IGF, PDGF, VEGF, P-selectin);whereas, in l-MND patients, a direct correlation was found with some analytes (CD19, IFNbeta), but an inverse one with others (EPO, IL6, sTNF-R1, PDGF, E and P selectins). We found that CD3, CD4, CD8, CD16, CD25, sIL6-R, IL5 and VCAM are differentially expressed in ALS and in l-MND patients. Conclusion: Our findings are useful as prognostic and diagnostic tools for ALS/MND patients. DOI: 10.1080/21678421.2017.1371525/0014
Blood inflammatory markers in motor neuron disease patients: pattern changes over time along disease progression
Bongioanni P;Dolciotti C;Bendinelli S;Cavalli L;Pelagatti A;Carboncini M.
2017-01-01
Abstract
In ALS patients, we observed a direct correlation between the ALSFRS scores and the levels of some blood analytes (CD3, CD16, CD25, IL17, CD44, sTNF-R2, VCAM, Eselectin) and an inverse correlation with others (CD19,sIL6-R, sTNF-R1, TGF, IGF, PDGF, VEGF, P-selectin);whereas, in l-MND patients, a direct correlation was found with some analytes (CD19, IFNbeta), but an inverse one with others (EPO, IL6, sTNF-R1, PDGF, E and P selectins). We found that CD3, CD4, CD8, CD16, CD25, sIL6-R, IL5 and VCAM are differentially expressed in ALS and in l-MND patients. Conclusion: Our findings are useful as prognostic and diagnostic tools for ALS/MND patients. DOI: 10.1080/21678421.2017.1371525/0014I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
