Critical limb ischemia (CLI) is the most advanced form of peripheral artery disease. It is associated with significant morbidity and mortality and high management costs. It carries a high risk of amputation and local infection. Moreover, cardiovascular complications remain a major concern. Although it is a well-known entity and new technological and therapeutic advances have been made, this condition remains poorly addressed, with significantly heterogeneous management, especially in nonexperienced centers. This review, from a third-level dedicated inpatient and outpatient cardioangiology structure, aims to provide an updated summary on the topic of CLI of its complexity, encompassing epidemiological, social, economical and, in particular, diagnostic/imaging issues, together with potential therapeutic strategies (medical, endovascular, and surgical), including the evaluation of cardiovascular risk factors, the diagnosis, and treatment together with prognostic stratification.

Critical Limb Ischemia: A Practical Up-To-Date Review

Fabiani, Iacopo;Calogero, Enrico;Pugliese, Nicola Riccardo;Di Stefano, Rossella;Barletta, Valentina
;
Berchiolli, Raffaella;Ferrari, Mauro;Di Bello, Vitantonio
2017

Abstract

Critical limb ischemia (CLI) is the most advanced form of peripheral artery disease. It is associated with significant morbidity and mortality and high management costs. It carries a high risk of amputation and local infection. Moreover, cardiovascular complications remain a major concern. Although it is a well-known entity and new technological and therapeutic advances have been made, this condition remains poorly addressed, with significantly heterogeneous management, especially in nonexperienced centers. This review, from a third-level dedicated inpatient and outpatient cardioangiology structure, aims to provide an updated summary on the topic of CLI of its complexity, encompassing epidemiological, social, economical and, in particular, diagnostic/imaging issues, together with potential therapeutic strategies (medical, endovascular, and surgical), including the evaluation of cardiovascular risk factors, the diagnosis, and treatment together with prognostic stratification.
Fabiani, Iacopo; Calogero, Enrico; Pugliese, Nicola Riccardo; Di Stefano, Rossella; Nicastro, Irene; Buttitta, Flavio; Nuti, Marco; Violo, Caterina; Giannini, Danilo; Morgantini, Alessandro; Conte, Lorenzo; Barletta, Valentina; Berchiolli, Raffaella; Adami, Daniele; Ferrari, Mauro; Di Bello, Vitantonio
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/881711
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