Biofabrication holds the potential to generate constructs that more closely recapitulate the complexity and heterogeneity of tissues and organs than do currently available regenerative medicine therapies. Such constructs can be applied for tissue regeneration or as in vitro 3D models. Biofabrication is maturing and growing, and scientists with different backgrounds are joining this field, underscoring the need for unity regarding the use of terminology. We therefore believe that there is a compelling need to clarify the relationship between the different concepts, technologies, and descriptions of biofabrication that are often used interchangeably or inconsistently in the current literature. Our objective is to provide a guide to the terminology for different technologies in the field which may serve as a reference for the biofabrication community. Biofabrication holds great potential in the fields of regenerative medicine and physiological 3D in vitro models by allowing the manufacture of complex tissue constructs with a higher degree of biomimicry to native tissues than do current biomedical solutions.As the number of biofabrication technologies being developed continues to expand, it is of paramount importance to adopt a concerted terminology framework and avoid generalizations.The ratio between the spatial resolution and the timescale of manufacture could be considered as a reliable measure to aid in the selection of an appropriate biofabrication technology for a desired application.

Biofabrication: A Guide to Technology and Terminology

De Maria, Carmelo;Vozzi, Giovanni
2017

Abstract

Biofabrication holds the potential to generate constructs that more closely recapitulate the complexity and heterogeneity of tissues and organs than do currently available regenerative medicine therapies. Such constructs can be applied for tissue regeneration or as in vitro 3D models. Biofabrication is maturing and growing, and scientists with different backgrounds are joining this field, underscoring the need for unity regarding the use of terminology. We therefore believe that there is a compelling need to clarify the relationship between the different concepts, technologies, and descriptions of biofabrication that are often used interchangeably or inconsistently in the current literature. Our objective is to provide a guide to the terminology for different technologies in the field which may serve as a reference for the biofabrication community. Biofabrication holds great potential in the fields of regenerative medicine and physiological 3D in vitro models by allowing the manufacture of complex tissue constructs with a higher degree of biomimicry to native tissues than do current biomedical solutions.As the number of biofabrication technologies being developed continues to expand, it is of paramount importance to adopt a concerted terminology framework and avoid generalizations.The ratio between the spatial resolution and the timescale of manufacture could be considered as a reliable measure to aid in the selection of an appropriate biofabrication technology for a desired application.
Moroni, Lorenzo; Boland, Thomas; Burdick, Jason A.; De Maria, Carmelo; Derby, Brian; Forgacs, Gabor; Groll, Jã¼rgen; Li, Qing; Malda, Jos; Mironov, Vladimir A.; Mota, Carlos; Nakamura, Makoto; Shu, Wenmiao; Takeuchi, Shoji; Woodfield, Tim B. F.; Xu, Tao; Yoo, James J.; Vozzi, Giovanni
File in questo prodotto:
File Dimensione Formato  
Biofabrication A Guide to Technology and Terminology.pdf

accesso aperto

Descrizione: preprint del paper
Tipologia: Documento in Pre-print
Licenza: Creative commons
Dimensione 914.75 kB
Formato Adobe PDF
914.75 kB Adobe PDF Visualizza/Apri
1-s2.0-S0167779917302792-main.pdf

solo utenti autorizzati

Tipologia: Versione finale editoriale
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 4.17 MB
Formato Adobe PDF
4.17 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/885392
Citazioni
  • ???jsp.display-item.citation.pmc??? 86
  • Scopus 295
  • ???jsp.display-item.citation.isi??? 268
social impact