Nanopatterning of proteins is important for many bio-diagnostic applications. We report on 200-nm scale patterning of thin films of proteins, by a specifically designed soft lithographic technique. This employs an elastomeric replica of a master, whose patterned side is firstly spin-coated by the protein and then turned upside down on a glass substrate. The patterned protein film is completely transferred to the substrate, exploiting the hydrophobic character of the elastomer. The process completely preserves the properties of biological matter, as it operates at room temperature and it does not require any bio-destructive solvent.
Sub-micron lithography on proteins by room temperature transfer molding
PISIGNANO, DARIO
2003-01-01
Abstract
Nanopatterning of proteins is important for many bio-diagnostic applications. We report on 200-nm scale patterning of thin films of proteins, by a specifically designed soft lithographic technique. This employs an elastomeric replica of a master, whose patterned side is firstly spin-coated by the protein and then turned upside down on a glass substrate. The patterned protein film is completely transferred to the substrate, exploiting the hydrophobic character of the elastomer. The process completely preserves the properties of biological matter, as it operates at room temperature and it does not require any bio-destructive solvent.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
