Depression in schizophrenia represents a challenge from a diagnostic, psychopathological and therapeutic perspective. The objective of this study is to test the hypothesis that resilience and self-stigma affect depression severity and to evaluate the strength of their relations in 921 patients with schizophrenia. A structural equation model was tested where depression is hypothesized as affected by resilience, internalized stigma, gender and negative symptoms, with the latter two variables used as exogenous covariates and the former two as mediators. The analysis reveals that low resilience, high negative symptoms, female gender were directly associated with depression severity, and internalized stigma acted only as a mediator between avolition and resilience, with similar magnitude. The cross-sectional study design and the variable selection limit the generalizability of the study results. The model supports a complex interaction between personal resources and negative symptoms in predicting depression in schizophrenia. The clinical implication of these findings is that personal resources could be a significant target of psychosocial treatments.

Personal resources and depression in schizophrenia: The role of self-esteem, resilience and internalized stigma

Galderisi, Silvana;Rucci, Paola;Stratta, Paolo;Dell'Osso, Liliana;Ferrari, Barbara;Gesi, Camilla;Rutigliano, Grazia;Landi, Paola;
2017-01-01

Abstract

Depression in schizophrenia represents a challenge from a diagnostic, psychopathological and therapeutic perspective. The objective of this study is to test the hypothesis that resilience and self-stigma affect depression severity and to evaluate the strength of their relations in 921 patients with schizophrenia. A structural equation model was tested where depression is hypothesized as affected by resilience, internalized stigma, gender and negative symptoms, with the latter two variables used as exogenous covariates and the former two as mediators. The analysis reveals that low resilience, high negative symptoms, female gender were directly associated with depression severity, and internalized stigma acted only as a mediator between avolition and resilience, with similar magnitude. The cross-sectional study design and the variable selection limit the generalizability of the study results. The model supports a complex interaction between personal resources and negative symptoms in predicting depression in schizophrenia. The clinical implication of these findings is that personal resources could be a significant target of psychosocial treatments.
2017
Rossi, Alessandro; Galderisi, Silvana; Rocca, Paola; Bertolino, Alessandro; Rucci, Paola; Gibertoni, Dino; Stratta, Paolo; Bucci, Paola; Mucci, Armida; Aguglia, Eugenio; Amodeo, Giovanni; Amore, Mario; Bellomo, Antonello; Brugnoli, Roberto; Caforio, Grazia; Carpiniello, Bernardo; Dell'Osso, Liliana; di Fabio, Fabio; di Giannantonio, Massimo; Marchesi, Carlo; Monteleone, Palmiero; Montemagni, Cristiana; Oldani, Lucio; Roncone, Rita; Sacchetti, Emilio; Santonastaso, Paolo; Siracusano, Alberto; Zeppegno, Patrizia; Maj, Mario; Andriola, Ileana; Paladini, Vittoria; Mancini, Marina; Ferrari, Barbara; Vita, Antonio; Barlati, Stefano; Galluzzo, Alessandro; Pinna, Federica; Primavera, Diego; Sanna, Lucia; Signorelli, Maria Salvina; Cannavã², Dario; Minutolo, Giuseppe; Martinotti, Giovanni; Lupi, Matteo; Corbo, Mariangela; Ricca, Valdo; Burchi, Elisabetta; Altamura, Mario; Carnevale, Raffaella; Petito, Annamaria; Murri, Martino Belvederi; Calcagno, Pietro; Corso, Alessandro; Rossetti, Maria Cristina; Rossi, Rodolfo; Santarelli, Valeria; Giusti, Laura; Malavolta, Maurizio; Ussorio, Donatella; Serati, Marta; De Simone, Stefania; Vignapiano, Annarita; Montefusco, Valentina; Plescia, Giuseppe Maria; Palumbo, Davide; Iasevoli, Felice; Gramaglia, Carla; Feggi, Alessandro; Gattoni, Eleonora; Campagnola, Nadia; Collantoni, Enrico; Tenconi, Elena; De Panfilis, Chiara; Tonna, Matteo; Ossola, Paolo; Gesi, Camilla; Rutigliano, Grazia; Landi, Paola; Biondi, Massimo; Girardi, Paolo; Buzzanca, Antonino; Comparelli, Anna; De Carolis, Antonella; Di Lorenzo, Giorgio; Niolu, Cinzia; Ribolsi, Michele; Corrivetti, Giulio; Bartoli, Luca; Diasco, Ferdinando; Fagiolini, Andrea; Goracci, Arianna; Bolognesi, Simone; Bava, Irene; Mancini, Irene; Cardillo, Simona
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/887458
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 17
  • Scopus 50
  • ???jsp.display-item.citation.isi??? ND
social impact