Stress ossidativo, alterazioni dell’HMGCoA reduttasi e del metabolismo degli isoprenoidi, e patogenesi dell’ipercolesterolemia dell’anziano

The aging process enhances oxidative stress and causes an alteration in membrane lipid and an increase in dolichol tissue levels and rate of synthesis and an increase in cholesterol synthesis and plasma levels. Recent observations show that changes in dolichol and cholesterol synthesis are secondary to a constitutive activation of HMGCoA activity, which may be caused by the ageing-dependent increase in oxidative stress in membranes.