Alzheimer's disease biomarker-guided diagnostic workflow using the added value of six combined cerebrospinal fluid candidates: Aβ1-42, total-tau, phosphorylated-tau, NFL, neurogranin, and YKL-40

Hampel, Harald; Toschi, Nicola; Baldacci, Filippo; Zetterberg, Henrik; Blennow, Kaj; Kilimann, Ingo; Teipel, Stefan J; Cavedo, Enrica; Dos Santos, Antonio Melo; Epelbaum, Stéphane; Lamari, Foudil; Genthon, Remy; Dubois, Bruno; Floris, Roberto; Garaci, Francesco; Lista, Simone

doi:10.1016/j.jalz.2017.11.015

The diagnostic and classificatory performances of all combinations of three core (amyloid β peptide [i.e., Aβ1-42], total tau [t-tau], and phosphorylated tau) and three novel (neurofilament light chain protein, neurogranin, and YKL-40) cerebrospinal fluid biomarkers of neurodegeneration were compared among individuals with mild cognitive impairment (n = 41), Alzheimer's disease dementia (ADD; n = 35), frontotemporal dementia (FTD; n = 9), and cognitively healthy controls (HC; n = 21), using 10-fold cross-validation.

Alzheimer's disease biomarker-guided diagnostic workflow using the added value of six combined cerebrospinal fluid candidates: Aβ1-42, total-tau, phosphorylated-tau, NFL, neurogranin, and YKL-40 / Hampel, Harald; Toschi, Nicola; Baldacci, Filippo; Zetterberg, Henrik; Blennow, Kaj; Kilimann, Ingo; Teipel, Stefan J; Cavedo, Enrica; Dos Santos, Antonio Melo; Epelbaum, Stéphane; Lamari, Foudil; Genthon, Remy; Dubois, Bruno; Floris, Roberto; Garaci, Francesco; Lista, Simone. - In: ALZHEIMER'S & DEMENTIA. - ISSN 1552-5260. - ELETTRONICO. - (2018).

Autori interni:	Hampel, Harald Toschi, Nicola BALDACCI, FILIPPO Zetterberg, Henrik Blennow, Kaj Kilimann, Ingo Teipel, Stefan J Cavedo, Enrica Dos Santos, Antonio Melo Epelbaum, Stéphane Lamari, Foudil Genthon, Remy Dubois, Bruno Floris, Roberto Garaci, Francesco Lista, Simone mostra contributor esterni nascondi contributor esterni
Autori:	Hampel, Harald; Toschi, Nicola; Baldacci, Filippo; Zetterberg, Henrik; Blennow, Kaj; Kilimann, Ingo; Teipel, Stefan J; Cavedo, Enrica; Dos Santos, Antonio Melo; Epelbaum, Stéphane; Lamari, Foudil; Genthon, Remy; Dubois, Bruno; Floris, Roberto; Garaci, Francesco; Lista, Simone
Titolo:	Alzheimer's disease biomarker-guided diagnostic workflow using the added value of six combined cerebrospinal fluid candidates: Aβ1-42, total-tau, phosphorylated-tau, NFL, neurogranin, and YKL-40
Anno del prodotto:	2018
Digital Object Identifier (DOI):	10.1016/j.jalz.2017.11.015
Appare nelle tipologie:	1.1 Articolo in rivista

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