This study aimed to determine whether the ovaries synthesize estradiol (E2), testosterone (T), and androstenedione (A) after menopause. The first group (30 patients) underwent surgical menopause (SM) â their ovaries were removed due to a benign condition around the time of menopause. The second group (30 patients) consisted of patients with natural menopause (NM). The E2 median level was 10.0âpg/ml (CIâ±â2.18) and 9.5âpg/ml (CIâ±â1.63) in the NM and SM groups (pâ=â.69), respectively. The median level of total T was 0.12âng/ml (CIâ±â0.01) and 0.11âng/ml (CIâ±â0.03) in NM and SM, respectively (pâ=â.96). The median level of A was 783.85âpg/ml (CIâ±â154.39) and 883.48âpg/dl (CIâ±â201.03) in NM and SM, respectively (pâ=â.57). The FAI (free androgen index) was 1.06 (CIâ±â0.24) and 1.35 (CIâ±â0.68) for NM and SM, respectively (pâ=â.98). We concluded that 5â10âyears after menopause the ovaries are no longer relevant for sex steroid synthesis.
How long is the ovary relevant for synthesis of steroids after menopause?
Simoncini, TommasoWriting – Review & Editing
;
2017-01-01
Abstract
This study aimed to determine whether the ovaries synthesize estradiol (E2), testosterone (T), and androstenedione (A) after menopause. The first group (30 patients) underwent surgical menopause (SM) â their ovaries were removed due to a benign condition around the time of menopause. The second group (30 patients) consisted of patients with natural menopause (NM). The E2 median level was 10.0âpg/ml (CIâ±â2.18) and 9.5âpg/ml (CIâ±â1.63) in the NM and SM groups (pâ=â.69), respectively. The median level of total T was 0.12âng/ml (CIâ±â0.01) and 0.11âng/ml (CIâ±â0.03) in NM and SM, respectively (pâ=â.96). The median level of A was 783.85âpg/ml (CIâ±â154.39) and 883.48âpg/dl (CIâ±â201.03) in NM and SM, respectively (pâ=â.57). The FAI (free androgen index) was 1.06 (CIâ±â0.24) and 1.35 (CIâ±â0.68) for NM and SM, respectively (pâ=â.98). We concluded that 5â10âyears after menopause the ovaries are no longer relevant for sex steroid synthesis.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.