Objective: The study aimed to explore premorbid academic and social functioning in patients with schizophrenia, and its associations with the severity of negative symptoms and neurocognitive impairment. Method: Premorbid adjustment (PA) in patients with schizophrenia was compared to early adjustment in unaffected first-degree relatives and healthy controls. Its associations with psychopathology, cognition, and real-life functioning were investigated. The associations of PA with primary negative symptoms and their two factors were explored. Results: We found an impairment of academic and social PA in patients (P ≤ 0.000001) and an impairment of academic aspects of early adjustment in relatives (P ≤ 0.01). Patients with poor PA showed greater severity of negative symptoms (limited to avolition after excluding the effect of depression/parkinsonism), working memory, social cognition, and real-life functioning (P ≤ 0.01 to ≤0.000001). Worse academic and social PA were associated with greater severity of psychopathology, cognitive impairment, and real-life functioning impairment (P ≤ 0.000001). Regression analyses showed that worse PA in the academic domain was mainly associated to the impairment of working memory, whereas worse PA in the social domain to avolition (P ≤ 0.000001). Conclusion: Our findings suggest that poor early adjustment may represent a marker of vulnerability to schizophrenia and highlight the need for preventive/early interventions based on psychosocial and/or cognitive programs.

Premorbid academic and social functioning in patients with schizophrenia and its associations with negative symptoms and cognition

Galderisi, Silvana;D'Amore, Manuela Fortunata Luigia;BELLOMO, ALESSANDRO;dell'Osso, L.;Barone, Marina;Carmassi, Claudia;Cremone, Ivan Mirko;Carpita, Barbara;
2018

Abstract

Objective: The study aimed to explore premorbid academic and social functioning in patients with schizophrenia, and its associations with the severity of negative symptoms and neurocognitive impairment. Method: Premorbid adjustment (PA) in patients with schizophrenia was compared to early adjustment in unaffected first-degree relatives and healthy controls. Its associations with psychopathology, cognition, and real-life functioning were investigated. The associations of PA with primary negative symptoms and their two factors were explored. Results: We found an impairment of academic and social PA in patients (P ≤ 0.000001) and an impairment of academic aspects of early adjustment in relatives (P ≤ 0.01). Patients with poor PA showed greater severity of negative symptoms (limited to avolition after excluding the effect of depression/parkinsonism), working memory, social cognition, and real-life functioning (P ≤ 0.01 to ≤0.000001). Worse academic and social PA were associated with greater severity of psychopathology, cognitive impairment, and real-life functioning impairment (P ≤ 0.000001). Regression analyses showed that worse PA in the academic domain was mainly associated to the impairment of working memory, whereas worse PA in the social domain to avolition (P ≤ 0.000001). Conclusion: Our findings suggest that poor early adjustment may represent a marker of vulnerability to schizophrenia and highlight the need for preventive/early interventions based on psychosocial and/or cognitive programs.
Bucci, P.; Galderisi, Silvana; Mucci, A.; Rossi, A.; Rocca, P.; Bertolino, A.; Aguglia, E.; D'Amore, Manuela Fortunata Luigia; Andriola, I.; Bellomo, Alessandro; Biondi, M.; Cuomo, A.; Dell'Osso, L.; Favaro, A.; Gambi, F.; Giordano, G. M.; Girardi, P.; Marchesi, C.; Monteleone, P.; Montemagni, C.; Niolu, C.; Oldani, L.; Pacitti, F.; Pinna, F.; Roncone, R.; Vita, A.; Zeppegno, P.; Maj, M.; Patriarca, Sara; Pietrafesa, Daria; Aiello, Carmen; Longo, Luisa; Barone, Marina; Romano, Raffaella; Atti, Anna Rita; Barlati, Stefano; Deste, Giacomo; Valsecchi, Paolo; Carpiniello, Bernardo; Tusconi, Massimo; Puddu, Laura; Signorelli, Maria Salvina; Cannavò, Dario; Minutolo, Giuseppe; Corbo, Mariangela; Montemitro, Chiara; Baroni, Gaia; Altamura, Mario; La Montagna, Maddalena; Carnevale, Raffaella; Murri, Martino Belvederi; Calcagno, Pietro; Bugliani, Michele; Pizziconi, Giulia; Logozzo, Francesca; Rossi, Rodolfo; Giusti, Laura; Salza, Anna; Malavolta, Maurizio; Orsenigo, Giulia; Grassi, Silvia; De Bartolomeis, Andrea; Gramaglia, Carla; Gattoni, Eleonora; Gambaro, Eleonora; Tenconi, Elena; Ferronato, Luisa; Collantoni, Enrico; Tonna, Matteo; Ossola, Paolo; Gerra, Maria Lidia; Carmassi, Claudia; Cremone, Ivan Mirko; Carpita, Barbara; Buzzanca, Antonio; Girardi, Nicoletta; Frascarelli, Marianna; Del Casale, Antonio; Comparelli, Anna; Corigliano, Valentina; Siracusano, Alberto; Di Lorenzo, Giorgio; Ribolsi, Michele; Corrivetti, Giulio; Bartoli, Luca; Del Buono, Gianfranco; Fagiolini, Andrea; Bolognesi, Simone; Goracci, Arianna; Mancini, Irene; Bava, Irene; Cardillo, Simona
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/927471
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