Background: Daptomycin pharmacokinetics has not been extensively studied in patients undergoing continuous renal replacement therapy (CRRT). Methods: The aim of the study was to collect pharmacokinetics and clinical data of patients undergoing CRRT and receiving daptomycin therapy. Daptomycin was measured using an isocratic high-performance liquid chromatography technique. Results: Three patients with bloodstream infection underwent CVVHD and three CVVHDF. CVVHDF patients had significantly lower mean AUC(0-24) and C-max values. A significant decrease in plasma levels was observed in a CVVHDF patient using 'high cut-off' hemofilters. Conclusion: Increasing doses of daptomycin should be considered in critical patients, especially those undergoing CVVHDF.

Daptomycin serum levels in critical patients undergoing continuous renal replacement

Marco Falcone;
2012-01-01

Abstract

Background: Daptomycin pharmacokinetics has not been extensively studied in patients undergoing continuous renal replacement therapy (CRRT). Methods: The aim of the study was to collect pharmacokinetics and clinical data of patients undergoing CRRT and receiving daptomycin therapy. Daptomycin was measured using an isocratic high-performance liquid chromatography technique. Results: Three patients with bloodstream infection underwent CVVHD and three CVVHDF. CVVHDF patients had significantly lower mean AUC(0-24) and C-max values. A significant decrease in plasma levels was observed in a CVVHDF patient using 'high cut-off' hemofilters. Conclusion: Increasing doses of daptomycin should be considered in critical patients, especially those undergoing CVVHDF.
2012
Falcone, Marco; Russo, Alessandro; Iris Cassetta, Maria; Lappa, Angela; Tritapepe, Luigi; Fallani, Stefania; Vullo, Vincenzo; Venditti, Mario; Novelli...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/928291
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