Trigeminal input to noradrenergic Locus Coeruleus (LC) neurons is important for the maintenance of arousal and may boost cognitive performance. Since it has been shown that LC enhances discrimination of acoustic stimuli and the associated electroencephalographic (EEG) waves, such as event related potentials (ERPs) P300, we set a protocol aimed to verify whether trigeminal nerve stimulation (TNS) may be utilized for improving acoustic discrimination of different tones. In two separate experiments, we evaluated P300 ERPs elicited by an acoustic oddball paradigm performed before and after TNS or sham-TNS, respectively. The ultimate purpose of this evaluation is to verify whether it is possible to exploit TNS as a treatment in subjects with disorders of consciousness.
Possible effect of the trigeminal nerve stimulation on auditory event-related potentials
M. P. Tramonti Fantozzi;F. Artoni;L. Briscese;D. Manzoni;T. Banfi;U. Faraguna;M. C. Carboncini
2019-01-01
Abstract
Trigeminal input to noradrenergic Locus Coeruleus (LC) neurons is important for the maintenance of arousal and may boost cognitive performance. Since it has been shown that LC enhances discrimination of acoustic stimuli and the associated electroencephalographic (EEG) waves, such as event related potentials (ERPs) P300, we set a protocol aimed to verify whether trigeminal nerve stimulation (TNS) may be utilized for improving acoustic discrimination of different tones. In two separate experiments, we evaluated P300 ERPs elicited by an acoustic oddball paradigm performed before and after TNS or sham-TNS, respectively. The ultimate purpose of this evaluation is to verify whether it is possible to exploit TNS as a treatment in subjects with disorders of consciousness.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
