Occurrence of multiple primary lung cancers (MPLC) in individuals undergoing low-dose computed tomography (LDCT) screening has not been thoroughly addressed. We investigated MPLC in subjects recruited in the ITALUNG randomized clinical trial. Cases of cytologically/histologically proven MPLC detected at screening LDCT or follow-up CT were selected and pathologically re-evaluated according to the WHO 2015 classification. Overall 16 MPLC were diagnosed at screening LDCT (n=14, all present at baseline) or follow-up CT (n=2) in six subjects (4 in one subject, 3 in two and 2 in three subjects), representing 0.43% of the 1,406 screenees and 15.8% of the 38 subjects with at least one screen-detected primary lung cancer. MPLC included 9 adenocarcinomas in three subjects and a combination of 7 different tumour histotypes in three subjects. MPLC, mostly adenocarcinomas, are not uncommon in smokers and ex-smokers with at least one LDCT screen detected primary lung cancer.

Screen-detected multiple primary lung cancers in the ITALUNG trial

Carrozzi, Laura;Fontanini, Gabriella;Pistelli, Francesco;Mussi, Alfredo;Lucchi, Marco;
2018

Abstract

Occurrence of multiple primary lung cancers (MPLC) in individuals undergoing low-dose computed tomography (LDCT) screening has not been thoroughly addressed. We investigated MPLC in subjects recruited in the ITALUNG randomized clinical trial. Cases of cytologically/histologically proven MPLC detected at screening LDCT or follow-up CT were selected and pathologically re-evaluated according to the WHO 2015 classification. Overall 16 MPLC were diagnosed at screening LDCT (n=14, all present at baseline) or follow-up CT (n=2) in six subjects (4 in one subject, 3 in two and 2 in three subjects), representing 0.43% of the 1,406 screenees and 15.8% of the 38 subjects with at least one screen-detected primary lung cancer. MPLC included 9 adenocarcinomas in three subjects and a combination of 7 different tumour histotypes in three subjects. MPLC, mostly adenocarcinomas, are not uncommon in smokers and ex-smokers with at least one LDCT screen detected primary lung cancer.
Mascalchi, Mario; Comin, Camilla E.; Bertelli, Elena; Sali, Lapo; Maddau, Cristina; Zuccherelli, Stefania; Picozzi, Giulia; Carrozzi, Laura; Grazzini, Michela; Fontanini, Gabriella; Voltolini, Luca; Vella, Alessandra; Castiglione, Francesca; Carozzi, Francesca; Paci, Eugenio; Zompatori, Maurizio; Pegna, Andrea Lopes; Falaschi, Fabio; Bianchi, Roberto; Ronchi, Cristina; Aquilini, Ferruccio; Cini, Stella; De Santis, Mariella; Pistelli, Francesco; Baliva, Filomena; Chella, Antonio; Tavanti, Laura; Innocenti, Florio; Natali, Ilaria; Bartolucci, Maurizio; Crisci, Elena; De Francisci, Agostino; Falchini, Massimo; Gabbrielli, Silvia; Roselli, Giuliana; Masi, Andrea; Battola, Luigi; De Liperi, Anna Lisa; Spinelli, Cheti; Vannucchi, Letizia; Petruzzelli, Alessia; Gadda, Davide; Neri, Anna Talina; Niccolai, Franco; Vaggelli, Luca; Carozzi, Francesca Maria; Janni, Alberto; Mussi, Alfredo; Lucchi, Marco; Comin, Camilla; Tognetti, Adele Renza; Cordopatri, Giovanna; Giusti, Francesco; Esposito, Ida
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/935542
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