Matrix metalloproteinases (MMPs) have been proposed as markers of many pathological conditions for their ability to degrade extracellular matrix components and remodel tissues. This review presents an overview of biosensors for the measurement of MMPs in serum, sputum and cell cultures. Major benefits and limitations of these technologies are discussed with respect to zymography and immunoassays, which are the reference methods to measure MMP activity and concentration. The paper also compares the analytical performances of sensors to the specific requirements for the application in clinical research, and comments on future trends in this field.

Biosensors for measuring matrix metalloproteinases: An emerging research field

Poma, Noemi;Melai, Bernardo;VIVALDI, FEDERICO MARIA;Franzini, Maria;Caponi, Laura;Tavanti, Arianna;Di Francesco, Fabio
Ultimo
2019-01-01

Abstract

Matrix metalloproteinases (MMPs) have been proposed as markers of many pathological conditions for their ability to degrade extracellular matrix components and remodel tissues. This review presents an overview of biosensors for the measurement of MMPs in serum, sputum and cell cultures. Major benefits and limitations of these technologies are discussed with respect to zymography and immunoassays, which are the reference methods to measure MMP activity and concentration. The paper also compares the analytical performances of sensors to the specific requirements for the application in clinical research, and comments on future trends in this field.
2019
Kirchhain, Arno; Poma, Noemi; Salvo, Pietro; Tedeschi, Lorena; Melai, Bernardo; Vivaldi, FEDERICO MARIA; Bonini, Andrea; Franzini, Maria; Caponi, Laura; Tavanti, Arianna; Di Francesco, Fabio
File in questo prodotto:
File Dimensione Formato  
BiosensorsMMPRevised Manuscript v6.2merged.pdf

accesso aperto

Descrizione: VersioneRevisedText
Tipologia: Documento in Post-print
Licenza: Creative commons
Dimensione 2.16 MB
Formato Adobe PDF
2.16 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/943933
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 30
  • ???jsp.display-item.citation.isi??? 25
social impact