Extended-spectrum β-lactamases mediate resistance to third-generation cephalosporins (eg, ceftriaxone) in Escherichia coli and Klebsiella pneumoniae. Significant infections caused by these strains are usually treated with carbapenems, potentially selecting for carbapenem resistance. Piperacillin-tazobactam may be an effective "carbapenem-sparing" option to treat extended-spectrum β-lactamase producers.

Effect of Piperacillin-Tazobactam vs Meropenem on 30-Day Mortality for Patients With E coli or Klebsiella pneumoniae Bloodstream Infection and Ceftriaxone Resistance: A Randomized Clinical Trial

Falcone, Marco;
2018-01-01

Abstract

Extended-spectrum β-lactamases mediate resistance to third-generation cephalosporins (eg, ceftriaxone) in Escherichia coli and Klebsiella pneumoniae. Significant infections caused by these strains are usually treated with carbapenems, potentially selecting for carbapenem resistance. Piperacillin-tazobactam may be an effective "carbapenem-sparing" option to treat extended-spectrum β-lactamase producers.
2018
Harris, Patrick N A; Tambyah, Paul A; Lye, David C; Mo, Yin; Lee, Tau H; Yilmaz, Mesut; Alenazi, Thamer H; Arabi, Yaseen; Falcone, Marco; Bassetti, Matteo; Righi, Elda; Rogers, Benjamin A; Kanj, Souha; Bhally, Hasan; Iredell, Jon; Mendelson, Marc; Boyles, Tom H; Looke, David; Miyakis, Spiros; Walls, Genevieve; Al Khamis, Mohammed; Zikri, Ahmed; Crowe, Amy; Ingram, Paul; Daneman, Nick; Griffin, Paul; Athan, Eugene; Lorenc, Penelope; Baker, Peter; Roberts, Leah; Beatson, Scott A; Peleg, Anton Y; Harris-Brown, Tiffany; Paterson, David L
File in questo prodotto:
File Dimensione Formato  
JAMA_Harris_2018_oi_180090.pdf

solo utenti autorizzati

Tipologia: Documento in Post-print
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 416.82 kB
Formato Adobe PDF
416.82 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/944381
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 156
  • Scopus 471
  • ???jsp.display-item.citation.isi??? 455
social impact