Adenosine is an endogenous nucleoside, released into the extracellular space in response to metabolic stress and cell damage and critically involved in the maintenance of tissue integrity by modulation of the immune system. The magnitude and duration of adenosine signaling are dictated by the expression and activity of a plethora of synthetic and catabolic enzymes as well as nucleoside transporters, which calibrate finely the concentration of this nucleoside in the biophase of specific receptors. Indeed, once released into the extracellular space, adenosine governs several aspects of immune cell functions by interaction with four G-protein-coupled cell membrane receptors, designated as A1, A2A, A2B, and A3 receptors. The engagement of such receptors, expressed heterogeneously on the surface of several immune cell populations, including neutrophils, macrophages, dendritic cells, mast cells, and lymphocytes, shapes a broad array of immune cell functions, which include cytokine production, degranulation, chemotaxis, cytotoxicity, apoptosis, and proliferation.

Adenosine regulation of the immune system

Antonioli, Luca
Primo
;
Fornai, Matteo;Blandizzi, Corrado
Penultimo
;
2018

Abstract

Adenosine is an endogenous nucleoside, released into the extracellular space in response to metabolic stress and cell damage and critically involved in the maintenance of tissue integrity by modulation of the immune system. The magnitude and duration of adenosine signaling are dictated by the expression and activity of a plethora of synthetic and catabolic enzymes as well as nucleoside transporters, which calibrate finely the concentration of this nucleoside in the biophase of specific receptors. Indeed, once released into the extracellular space, adenosine governs several aspects of immune cell functions by interaction with four G-protein-coupled cell membrane receptors, designated as A1, A2A, A2B, and A3 receptors. The engagement of such receptors, expressed heterogeneously on the surface of several immune cell populations, including neutrophils, macrophages, dendritic cells, mast cells, and lymphocytes, shapes a broad array of immune cell functions, which include cytokine production, degranulation, chemotaxis, cytotoxicity, apoptosis, and proliferation.
Antonioli, Luca; Fornai, Matteo; Blandizzi, Corrado; Haskó, György
File in questo prodotto:
File Dimensione Formato  
Fornai_940959.pdf

solo utenti autorizzati

Tipologia: Versione finale editoriale
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 334.63 kB
Formato Adobe PDF
334.63 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/949059
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 6
  • ???jsp.display-item.citation.isi??? ND
social impact