Natural polyphenols have long attracted growing interest for their beneficial effects on human health. Oleuropein, present in olive leaves and oil drupes, is one of the main phenolic compounds recently studied. Among the various nutraceutical properties of oleuropein, its hypoglycemic power has found wide interest in human medicine. At present, the potential hypoglycemic effect of oleuropein in dogs has not yet been evaluated. The aim of this study was to evaluate the effect of oleuropein on glycemia in dogs. The study was carried out on 10 clinically healthy dogs. Subjects received for two weeks a nutritional supplement containing oleuropein at the dose of 2 mg/kg body wt/day. Prior to administration of the supplement and at the end of each week the postprandial glycemic curve was evaluated after administration of a carbohydrate-only meal (6 g starch/kg body wt). For the evaluation of the glycemic curve a rapid test (Pic GlucoTest) on capillary blood was used. Glycemia was evaluated on a fasting basis (T0) and after the meal at 30 (T30), 60 (T60), 90 (T90) and 120 (T120) minutes. Despite the short period of oleuropein administration, the results showed low blood glucose values and the tendency towards early stabilization even in the absence of statistical significance. Furthermore, a statistical significant effect of breed was found. These results certainly stimulate to continue the investigations with higher dosages and/or with prolonged administration in diabetic dogs as well.
Effect of Oleuropein on Glycemia in Dogs
Casini, Lucia
Primo
;
2018-01-01
Abstract
Natural polyphenols have long attracted growing interest for their beneficial effects on human health. Oleuropein, present in olive leaves and oil drupes, is one of the main phenolic compounds recently studied. Among the various nutraceutical properties of oleuropein, its hypoglycemic power has found wide interest in human medicine. At present, the potential hypoglycemic effect of oleuropein in dogs has not yet been evaluated. The aim of this study was to evaluate the effect of oleuropein on glycemia in dogs. The study was carried out on 10 clinically healthy dogs. Subjects received for two weeks a nutritional supplement containing oleuropein at the dose of 2 mg/kg body wt/day. Prior to administration of the supplement and at the end of each week the postprandial glycemic curve was evaluated after administration of a carbohydrate-only meal (6 g starch/kg body wt). For the evaluation of the glycemic curve a rapid test (Pic GlucoTest) on capillary blood was used. Glycemia was evaluated on a fasting basis (T0) and after the meal at 30 (T30), 60 (T60), 90 (T90) and 120 (T120) minutes. Despite the short period of oleuropein administration, the results showed low blood glucose values and the tendency towards early stabilization even in the absence of statistical significance. Furthermore, a statistical significant effect of breed was found. These results certainly stimulate to continue the investigations with higher dosages and/or with prolonged administration in diabetic dogs as well.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
