The effects of a few cytotoxic organogold(III) compounds on ovarian A2780 human cancer cells were investigated in comparison to cisplatin and oxaliplatin. The tested compounds produced significant antiproliferative effects and promoted apoptosis to a greater extent than platinum drugs while causing only modest cell cycle modifications. The mechanistic implications of these findings are discussed: mitochondrial pathways are proposed to be directly involved in the apoptotic process in relation to selective inhibition of thioredoxin reductase.
|Autori:||CORONNELLO M.; MINI E.; CACIAGLI B.; CINELLU; M.A.; BINDOLI A.; GABBIANI C.; L. MESSORI|
|Titolo:||MECHANISMS OF CYTOTOXICITY OF SELECTED ORGANOGOLD(III) COMPOUNDS|
|Anno del prodotto:||2005|
|Digital Object Identifier (DOI):||10.1021/jm050493o|
|Appare nelle tipologie:||1.1 Articolo in rivista|