We conducted a case-control study on asbestos exposure and presence of SV40 in tumor samples of malignant mesotheliomas (MMs) and bladder urotheliomas (BUs). PCR analysis revealed the presence of SV40 DNA (SV40+) in eight (42.1%) MAls and 6 (33.3%) BUs. The odds ratio for MM Ash- and SV40+ was 0.4 [95% confidence interval (95% CI), 0.03-4.0], for Asb+ and SV40- was 3.6 (95% Cl, 0.6-21.0), and for Asb+ and SV40+ was 12.6 (95% CI, 1.2-133.9). Our results suggest that SV40 increases the risk of MM among individuals exposed to asbestos.

SV40 ENHANCES THE RISK OF MALIGNANT MESOTHELIOMA AMONG PEOPLE EXPOSED TO ASBESTOS: A MOLECULAR EPIDEMIOLOGIC CASE-CONTROL STUDY

CRISTAUDO, ALFONSO;FODDIS, RUDY;GUGLIELMI, GIOVANNI;COSENTINO, FRANCESCA;OTTENGA, FRANCO;
2005-01-01

Abstract

We conducted a case-control study on asbestos exposure and presence of SV40 in tumor samples of malignant mesotheliomas (MMs) and bladder urotheliomas (BUs). PCR analysis revealed the presence of SV40 DNA (SV40+) in eight (42.1%) MAls and 6 (33.3%) BUs. The odds ratio for MM Ash- and SV40+ was 0.4 [95% confidence interval (95% CI), 0.03-4.0], for Asb+ and SV40- was 3.6 (95% Cl, 0.6-21.0), and for Asb+ and SV40+ was 12.6 (95% CI, 1.2-133.9). Our results suggest that SV40 increases the risk of MM among individuals exposed to asbestos.
2005
Cristaudo, Alfonso; Foddis, Rudy; Vivaldi, A; Buselli, R; Gattini, V; Guglielmi, Giovanni; Cosentino, Francesca; Ottenga, Franco; Ciancia, E; Libener,...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/98031
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