We tested the efficacy and safety of glutamine (0.6gm/kg/day) and creatine (5gm/day) in 50 ambulant boys with Duchenne muscular dystrophy in a 6-month, double-blind, placebo-controlled clinical trial. Drug efficacy was tested by measuring muscle strength manually (34 muscle groups) and quantitatively (10 muscle groups). Timed functional tests, functional parameters, and pulmonary function tests were secondary outcome measures. Although there was no statistically significant effect of either therapy based on manual and quantitative measurements of muscle strength, a disease-modifying effect of creatine in older Duchenne muscular dystrophy and creatine and glutamine in younger Duchenne muscular dystrophy cannot be excluded. Creatine and glutamine were well tolerated.
|Autori:||ESCOLAR DM; BUYSE G; HENRICSON E; LESHNER R; FLORENCE J; MAYHEW J; TESI-ROCHA C; GORNI K; PASQUALI L; PATEL KM; MCCARTER R; HUANG J; MAYHEW T; BERTORINI T; CARLO J; CONNOLLY AM; CLEMENS PR; GOEMANS N; IANNACCONE ST; IGARASHI M; NEVO Y; PESTRONK A; SUBRAMONY SH; VEDANARAYANAN VV; WESSEL H; CINRG GROUP|
|Titolo:||CINRG randomized controlled trial of creatine and glutamine in Duchenne muscular dystrophy|
|Anno del prodotto:||2005|
|Digital Object Identifier (DOI):||10.1002/ana.20523|
|Appare nelle tipologie:||1.1 Articolo in rivista|