Synthesis of a series of new cannabinoid receptor ligands obtained from the conjugation of 1,2-dihydro-2-oxo-pyridine-3-carboxamides portion of A or B with the anomeric or C(6) position of monosaccharide units (D-Gluco, D-galacto and GlcNAc). The new compounds were designed with the aim to increase hydrophilicity and activity of multitarget compounds A and of CB2R positive modulators B. The new compounds will be tested for their biocompatibility and biologically properties.
Synthesis of glyco-conjugates of 1,2-dihydro-2-oxo-pyridine-3-carboxamides as new modulators of endocannabinoid system
Francesca Gado;Marco Macchia;Clementina Manera;Felicia D’Andrea;Lorenzo Guazzelli;
2018-01-01
Abstract
Synthesis of a series of new cannabinoid receptor ligands obtained from the conjugation of 1,2-dihydro-2-oxo-pyridine-3-carboxamides portion of A or B with the anomeric or C(6) position of monosaccharide units (D-Gluco, D-galacto and GlcNAc). The new compounds were designed with the aim to increase hydrophilicity and activity of multitarget compounds A and of CB2R positive modulators B. The new compounds will be tested for their biocompatibility and biologically properties.File in questo prodotto:
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PDFsam_ATTI XVI-CSCC 2018.pdf
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