Here we report the synthesis and evaluation of antiplasmodial activity of a novel series of bicyclic peroxides inspired by the marine natural compound dihydroplakortin. We developed a synthetic strategy leading to the dihydroplakortin-related peroxides in only a few steps. The in vitro antiplasmodial potency of the peroxides was similar to, or greater than, that of the reference natural compound, and structure-activity relationship studies revealed several key structural requirements for activity and potency. © 2011 American Chemical Society.

Synthesis and antiplasmodial activity of bicyclic dioxanes as simplified dihydroplakortin analogues

Brogi S.;
2011-01-01

Abstract

Here we report the synthesis and evaluation of antiplasmodial activity of a novel series of bicyclic peroxides inspired by the marine natural compound dihydroplakortin. We developed a synthetic strategy leading to the dihydroplakortin-related peroxides in only a few steps. The in vitro antiplasmodial potency of the peroxides was similar to, or greater than, that of the reference natural compound, and structure-activity relationship studies revealed several key structural requirements for activity and potency. © 2011 American Chemical Society.
2011
Gemma, S.; Kunjir, S.; Sanna Coccone, S.; Brindisi, M.; Moretti, V.; Brogi, S.; Novellino, E.; Basilico, N.; Parapini, S.; Taramelli, D.; Campiani, G.; Butini, S.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/993614
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