To evaluate the relative impact of abdominal obesity and newly diagnosed type 2 diabetes on insulin action in skeletal muscle and fat tissue, we studied 61 men with (n = 31) or without (n = 30) diabetes; subgrouped into abdominally obese or nonobese according to the waist circumference. Adipose tissue depots were quantified by magnetic resonance imaging, and regional glucose uptake was measured using 2-[F-18]fluoro-2-deoxyglucose/positron emission tomography during euglycemic hyperinsulinemia. Across groups, glucose uptake per unit tissue weight was higher in visceral (20.5 +/- 1.4 mu mol . min(-1) . kg(-1)) than in abdominal (9.8 +/- 0.9 mu mol min(-1) . kg(-1), P < 0.001) or femoral (12.3 +/- 0.6 mu mol . min(-1). kg(-1), P < 0.001) subcutaneous tissue and similar to 40% lower than in skeletal muscle (33.1. +/- 2.5 mu mol . min(-1) . kg(-1), P < 0.0001). Abdominal obesity was associated with a marked reduction in glucose uptake per unit tissue weight in all fat depots and in skeletal muscle (P < 0.001 for all regions). Recent type 2 diabetes per se had little additional effect. In both intra-abdominal adipose (r = -0.73, P < 0.0001) and skeletal muscle (r = -0.53, P < 0.0001) tissue, glucose uptake was reciprocally related to intra-abdominal fat mass in a curvilinear fashion. When regional glucose uptake was multiplied by tissue mass, total glucose uptake per fat depot was similar irrespective of abdominal obesity or type 2 diabetes, and its contribution to whole-body glucose uptake increased by similar to 40% in obese nondiabetic and nonobese diabetic men and was doubled in obese diabetic subjects. We conclude that 1) in abdominal obesity, insulin-stimulated glucose uptake rate is markedly reduced in skeletal muscle and in all fat depots; 2) in target tissues, this reduction is reciprocally (and nonlinearly) related to the amount of intra-abdominal fat; 3) mild, recent diabetes adds little insulin resistance to that caused by abdominal obesity; and 4) despite fat insulin resistance, an expanded fat mass (especially subcutaneous) provides a sink for glucose, resulting in a compensatory attenuation of insulin resistance at the whole-body level in men.
|Autori:||Virtanen KA; Iozzo P; Hallsten K; Huupponen R; Parkkola R; Janatuinen T; Lonnqvist F; Viljanen T; Ronnemaa T; Lonnroth P; Knuuti J; Ferrannini E; Nuutila P|
|Titolo:||Increased fat mass compensates for insulin resistance in abdominal obesity and type 2 diabetes - A positron-emitting tomography study|
|Anno del prodotto:||2005|
|Digital Object Identifier (DOI):||10.2337/diabetes.54.9.2720|
|Appare nelle tipologie:||1.1 Articolo in rivista|