| Nome |
# |
|
Age-related macular degeneration: Current knowledge of zinc metalloproteinases involvement, file e0d6c92e-c96e-fcf8-e053-d805fe0aa794
|
361
|
|
Targeting ADAM17 Sheddase Activity in Cancer, file e0d6c930-a0fd-fcf8-e053-d805fe0aa794
|
320
|
|
Matrix metalloproteinase inhibitors prevent the release and proteolytic activity of monocyte/macrophage-derived microparticles, file e0d6c92c-1c8c-fcf8-e053-d805fe0aa794
|
175
|
|
Synthesis and antiangiogenic activity study of new hop chalcone Xanthohumol analogues, file e0d6c92b-fccf-fcf8-e053-d805fe0aa794
|
127
|
|
N-(aroyl)-N-(arylmethyloxy)-α-alanines: selective inhibitors of aldose reductase, file e0d6c92d-0177-fcf8-e053-d805fe0aa794
|
122
|
|
Activation of carbonic anhydrases from human brain by amino alcohol oxime ethers: towards human carbonic anhydrase VII selective activators, file e0d6c92f-a409-fcf8-e053-d805fe0aa794
|
117
|
|
Development of Thioaryl-Based Matrix Metalloproteinase-12 Inhibitors with Alternative Zinc-Binding Groups: Synthesis, Potentiometric, NMR, and Crystallographic Studies, file e0d6c930-b3d6-fcf8-e053-d805fe0aa794
|
114
|
|
Synthesis and cycloxygenase inhibitory properties of new naphthalene-methylsulfonamido, naphthalene-methylsulfonyl and tetrahydronaphthalen-methylsulfonamido compounds, file e0d6c928-f8fb-fcf8-e053-d805fe0aa794
|
98
|
|
null, file e0d6c929-b2d8-fcf8-e053-d805fe0aa794
|
98
|
|
Design and Synthesis of Ionic Liquid-Based Matrix Metalloproteinase Inhibitors (MMPIs): A Simple Approach to Increase Hydrophilicity and to Develop MMPI-Coated Gold Nanoparticles, file e0d6c92e-b34c-fcf8-e053-d805fe0aa794
|
90
|
|
Amino Acid Derivatives as New Zinc Binding Groups for the Design of Selective Matrix Metalloproteinase Inhibitors, file e0d6c926-3ad6-fcf8-e053-d805fe0aa794
|
84
|
|
null, file e0d6c92b-ae1b-fcf8-e053-d805fe0aa794
|
84
|
|
Design, synthesis and biological evaluation of bifunctional inhibitors of membrane type 1 matrix metalloproteinase (MT1-MMP), file e0d6c92c-3326-fcf8-e053-d805fe0aa794
|
74
|
|
Discovery of a new selective inhibitor of A Disintegrin And Metalloprotease 10 (ADAM-10) able to reduce the shedding of NKG2D ligands in Hodgkin's lymphoma cell models, file e0d6c930-b785-fcf8-e053-d805fe0aa794
|
72
|
|
Matrix metalloproteinase-12 inhibitors: synthesis, structure-activity relationships and intestinal absorption of novel sugar-based biphenylsulfonamide carboxylates, file e0d6c92b-7ce4-fcf8-e053-d805fe0aa794
|
68
|
|
N-O-Isopropyl Sulfonamido-Based Hydroxamates as Matrix Metalloproteinase Inhibitors: Hit Selection and in Vivo Antiangiogenic Activity, file e0d6c92c-1404-fcf8-e053-d805fe0aa794
|
68
|
|
Sugar-Based Arylsulfonamide Carboxylates as Selective and Water-Soluble Matrix Metalloproteinase-12 Inhibitors, file e0d6c930-be7f-fcf8-e053-d805fe0aa794
|
64
|
|
Selective Arylsulfonamide Inhibitors of ADAM-17: Hit Optimization and Activity in Ovarian Cancer Cell Models, file e0d6c92c-3829-fcf8-e053-d805fe0aa794
|
58
|
|
Ionic liquid-promoted green synthesis of biologically relevant diaryl thioethers, file e0d6c92f-1ec0-fcf8-e053-d805fe0aa794
|
52
|
|
Identification of histone deacetylase inhibitors with (arylidene)aminoxy scaffold active in uveal melanoma cell lines, file e0d6c92f-88ed-fcf8-e053-d805fe0aa794
|
49
|
|
Monoaryl derivatives as transthyretin fibril formation inhibitors: Design, synthesis, biological evaluation and structural analysis, file e0d6c92f-b2f4-fcf8-e053-d805fe0aa794
|
46
|
|
Exosite inhibition of ADAMTS-5 by a glycoconjugated arylsulfonamide, file e0d6c930-4cdd-fcf8-e053-d805fe0aa794
|
43
|
|
Synthesis, experimental evaluation and molecular modelling of hydroxamate derivatives as zinc metalloproteinase inhibitors, file e0d6c930-b172-fcf8-e053-d805fe0aa794
|
36
|
|
null, file e0d6c92f-ccb9-fcf8-e053-d805fe0aa794
|
35
|
|
Bifunctional Inhibitors as a New Tool To Reduce Cancer Cell Invasion by Impairing MMP-9 Homodimerization, file e0d6c930-9f49-fcf8-e053-d805fe0aa794
|
30
|
|
Analoghi sintetici dello xantumolo, file e0d6c929-8b0d-fcf8-e053-d805fe0aa794
|
24
|
|
Specific ADAM10 inhibitors localize in exosome-like vesicles released by Hodgkin lymphoma and stromal cells and prevent sheddase activity carried to bystander cells, file e0d6c92f-beb0-fcf8-e053-d805fe0aa794
|
16
|
|
Development of a fluorogenic ADAMTS-7 substrate, file e0d6c931-3fbd-fcf8-e053-d805fe0aa794
|
16
|
|
ADAM10 new selective inhibitors reduce NKG2D ligand release sensitizing Hodgkin lymphoma cells to NKG2D-mediated killing, file e0d6c92f-ccb6-fcf8-e053-d805fe0aa794
|
11
|
|
null, file e0d6c931-495b-fcf8-e053-d805fe0aa794
|
11
|
|
Inhibitors of A Disintegrin And Metalloproteinases-10 reduce Hodgkin lymphoma cell growth in 3D microenvironments and enhance brentuximab-vedotin effect, file e0d6c931-efac-fcf8-e053-d805fe0aa794
|
10
|
|
An overview of carbohydrate-based carbonic anhydrase inhibitors, file e0d6c92f-943f-fcf8-e053-d805fe0aa794
|
9
|
|
null, file e0d6c92e-40cc-fcf8-e053-d805fe0aa794
|
8
|
|
Discovery of a new selective inhibitor of A Disintegrin And Metalloprotease 10 (ADAM-10) able to reduce the shedding of NKG2D ligands in Hodgkin's lymphoma cell models, file e0d6c927-1453-fcf8-e053-d805fe0aa794
|
7
|
|
Targeting ADAM17 Sheddase Activity in Cancer, file e0d6c928-acc7-fcf8-e053-d805fe0aa794
|
7
|
|
Bifunctional Inhibitors as a New Tool To Reduce Cancer Cell Invasion by Impairing MMP-9 Homodimerization, file e0d6c928-ebfc-fcf8-e053-d805fe0aa794
|
7
|
|
Sugar-Based Arylsulfonamide Carboxylates as Selective and Water-Soluble Matrix Metalloproteinase-12 Inhibitors, file e0d6c928-f750-fcf8-e053-d805fe0aa794
|
7
|
|
Design and Synthesis of Ionic Liquid-Based Matrix Metalloproteinase Inhibitors (MMPIs): A Simple Approach to Increase Hydrophilicity and to Develop MMPI-Coated Gold Nanoparticles, file e0d6c92d-398d-fcf8-e053-d805fe0aa794
|
7
|
|
Compounds with a benzo [a]carbazole structure for use in the prevention and/or treatment of infectious diseases, file f0e23d74-e5d8-47c6-b567-7cac3b79ca7e
|
7
|
|
Sugar-Based Arylsulfonamide Carboxylates as Selective and Water-Soluble Matrix Metalloproteinase-12 Inhibitors, file e0d6c928-f806-fcf8-e053-d805fe0aa794
|
6
|
|
Arylsulfonamide inhibitors of aggrecanases as potential therapeutic agents for osteoarthritis: Synthesis and biological evaluation., file e0d6c926-35e2-fcf8-e053-d805fe0aa794
|
5
|
|
N-O-Isopropyl Sulfonamido-Based Hydroxamates as Matrix Metalloproteinase Inhibitors: Hit Selection and in Vivo Antiangiogenic Activity, file e0d6c926-9f90-fcf8-e053-d805fe0aa794
|
5
|
|
null, file e0d6c927-1197-fcf8-e053-d805fe0aa794
|
5
|
|
Development of Thioaryl-Based Matrix Metalloproteinase-12 Inhibitors with Alternative Zinc-Binding Groups: Synthesis, Potentiometric, NMR, and Crystallographic Studies, file e0d6c92b-2b99-fcf8-e053-d805fe0aa794
|
5
|
|
ADAM metalloproteinases as potential drug targets, file e0d6c92e-efa8-fcf8-e053-d805fe0aa794
|
5
|
|
Selective Arylsulfonamide Inhibitors of ADAM-17: Hit Optimization and Activity in Ovarian Cancer Cell Models, file e0d6c926-4074-fcf8-e053-d805fe0aa794
|
4
|
|
Synthesis and biological evaluation in U87MG
glioma cells of (ethynylthiophene)sulfonamido-based hydroxamates as matrix
metalloproteinase inhibitors, file e0d6c926-f864-fcf8-e053-d805fe0aa794
|
4
|
|
null, file e0d6c927-3d0b-fcf8-e053-d805fe0aa794
|
4
|
|
The metalloproteinase ADAM10 requires its activity to sustain surface expression, file e0d6c931-9d7e-fcf8-e053-d805fe0aa794
|
4
|
|
null, file e54202b2-7569-418c-afc7-ffe398a4a724
|
4
|
|
Discovery of Dimeric Arylsulfonamides as Potent ADAM8 Inhibitors, file a273f4a1-e859-4776-b878-870a6b05b831
|
3
|
|
Synthesis, experimental evaluation and molecular modelling of hydroxamate derivatives as zinc metalloproteinase inhibitors, file e0d6c927-1437-fcf8-e053-d805fe0aa794
|
3
|
|
Hepatitis C virus-induced NK cell activation causes metzincin-mediated CD16 cleavage and impaired antibody-dependent cytotoxicity, file e0d6c929-0870-fcf8-e053-d805fe0aa794
|
3
|
|
Bivalent Inhibitor with Selectivity for Trimeric MMP-9 Amplifies Neutrophil Chemotaxis and Enables Functional Studies on MMP-9 Proteoforms, file e0d6c92f-9a4e-fcf8-e053-d805fe0aa794
|
3
|
|
Identification of broad-spectrum mmp inhibitors by virtual screening, file e0d6c931-3fbc-fcf8-e053-d805fe0aa794
|
3
|
|
Strategies to target ADAM17 in disease: From its discovery to the iRhom revolution, file e0d6c931-571f-fcf8-e053-d805fe0aa794
|
3
|
|
New bifunctional metalloproteinase inhibitors: an integrated approach towards biological improvements and cancer therapy., file e0d6c926-3c3c-fcf8-e053-d805fe0aa794
|
2
|
|
Synthesis and Preliminary Evaluation in Tumor Bearing Mice of New
18F‑Labeled Arylsulfone Matrix Metalloproteinase Inhibitors as
Tracers for Positron Emission Tomography, file e0d6c926-3f14-fcf8-e053-d805fe0aa794
|
2
|
|
Selective Arylsulfonamide Inhibitors of ADAM-17: Hit Optimization and Activity in Ovarian Cancer Cell Models, file e0d6c926-4075-fcf8-e053-d805fe0aa794
|
2
|
|
In Vivo Imaging of Matrix Metalloproteinase 12 and Matrix Metalloproteinase 13 Activities in the Mouse Model of Collagen-Induced Arthritis, file e0d6c926-4317-fcf8-e053-d805fe0aa794
|
2
|
|
Synthetic analogs of xanthohumol for use in the prevention and/or treatment of tumors, file e0d6c926-453b-fcf8-e053-d805fe0aa794
|
2
|
|
Structural Insights on Carbonic Anhydrase Inhibitory Action, Isoform Selectivity, and Potency of Sulfonamides and Coumarins Incorporating Arylsulfonylureido Groups, file e0d6c926-453e-fcf8-e053-d805fe0aa794
|
2
|
|
Inhibition of pseudolysin and thermolysin by hydroxamate-based MMP inhibitors, file e0d6c926-4c6b-fcf8-e053-d805fe0aa794
|
2
|
|
MMP-8 Is Critical for Dexamethasone Therapy in Alkali-Burned Corneas Under Dry Eye Conditions, file e0d6c927-8783-fcf8-e053-d805fe0aa794
|
2
|
|
Synthesis and antiangiogenic activity study of new hop chalcone Xanthohumol analogues, file e0d6c929-9007-fcf8-e053-d805fe0aa794
|
2
|
|
Synthesis and in vitro Evaluation of ADAM10 and ADAM17 Highly Selective Bioimaging Probes, file e0d6c92b-6a74-fcf8-e053-d805fe0aa794
|
2
|
|
Matrix metalloproteinase-12 inhibitors: synthesis, structure-activity relationships and intestinal absorption of novel sugar-based biphenylsulfonamide carboxylates, file e0d6c92b-6fe5-fcf8-e053-d805fe0aa794
|
2
|
|
Monoaryl derivatives as transthyretin fibril formation inhibitors: Design, synthesis, biological evaluation and structural analysis, file e0d6c92f-eb90-fcf8-e053-d805fe0aa794
|
2
|
|
null, file e0d6c930-86b2-fcf8-e053-d805fe0aa794
|
2
|
|
Identification of a Novel p53 Modulator Endowed with Antitumoural and Antibacterial Activity through a Scaffold Repurposing Approach, file 01a3238b-df78-4bb1-9b4e-44984e2e1fa3
|
1
|
|
Bacterial Zinc Metalloenzyme Inhibitors: Recent Advances and Future Perspectives, file 54f7fc1b-5bec-4a8e-805f-4e9ce4b13ccd
|
1
|
|
Identification of N-Acyl Hydrazones as New Non-Zinc-Binding MMP-13 Inhibitors by Structure-Based Virtual Screening Studies and Chemical Optimization, file 6b421000-2151-4c93-a072-09d3be5ed303
|
1
|
|
New isoxazolidinyl-based N-alkylethanolamines as new activators of human brain carbonic anhydrases, file 6e88ce0c-d18a-46d6-a3f9-0a724a0446a6
|
1
|
|
Targeting Aggrecanases for Osteoarthritis Therapy: From Zinc Chelation to Exosite Inhibition, file 96bbb513-2670-4034-8ea6-8b1f961316cb
|
1
|
|
Developments in carbohydrate-based metzincin inhibitors, file c9cfbab0-2119-418d-9836-de67a7361c14
|
1
|
|
Novel 1-hydroxypiperazine-2,6-diones as new leads in the inhibition of metalloproteinases, file e0d6c926-237e-fcf8-e053-d805fe0aa794
|
1
|
|
Development of a receptor-based 3D-QSAR study for the analysis of MMP2, MMP3, and MMP9 inhibitors, file e0d6c926-2697-fcf8-e053-d805fe0aa794
|
1
|
|
Crystallization of bi-functional ligand protein complexes, file e0d6c926-39b7-fcf8-e053-d805fe0aa794
|
1
|
|
Arylsulfonamide derivatives, especially dimeric hydroxamic acid-containing amino acids, metalloproteases inhibitors and their preparation, pharmaceutical compositions and use in the treatment of degenerative disorders, file e0d6c926-4053-fcf8-e053-d805fe0aa794
|
1
|
|
Combining the tail and the ring approaches for obtaining potent and isoform-selective carbonic anhydrase inhibitors: Solution and X-ray crystallographic studies, file e0d6c926-4080-fcf8-e053-d805fe0aa794
|
1
|
|
null, file e0d6c926-fef9-fcf8-e053-d805fe0aa794
|
1
|
|
A new D2 dopamine receptor agonist allosterically modulates A2A adenosine receptor signalling by interacting with the A2A/D2 receptor heteromer, file e0d6c928-f65d-fcf8-e053-d805fe0aa794
|
1
|
|
Design, synthesis and biological evaluation of bifunctional inhibitors of membrane type 1 matrix metalloproteinase (MT1-MMP), file e0d6c92b-5717-fcf8-e053-d805fe0aa794
|
1
|
|
Metalloprotease inhibitor profiles of human ADAM8 in vitro and in cell-based assays, file e0d6c92d-7c08-fcf8-e053-d805fe0aa794
|
1
|
|
null, file e0d6c930-9f2c-fcf8-e053-d805fe0aa794
|
1
|
|
null, file e0d6c930-a09c-fcf8-e053-d805fe0aa794
|
1
|
|
N-(aroyl)-N-(arylmethyloxy)-α-alanines: selective inhibitors of aldose reductase, file e0d6c930-d21a-fcf8-e053-d805fe0aa794
|
1
|
| Totale |
2.745 |