Doublets plus anti-epidermal growth factor receptors (EGFRs) are the preferred upfront option for patients with left-sided RAS/BRAF wild-type metastatic colorectal cancer (mCRC). Initial therapy with FOLFOXIRI-bevacizumab is superior to doublets plus bevacizumab independently from primary tumor sidedness and RAS/BRAF status. No randomized comparison between FOLFOXIRI-bevacizumab versus doublets plus anti-EGFRs is available in left-sided RAS/BRAF wild-type mCRC.

FOLFOXIRI-Bevacizumab or FOLFOX-Panitumumab in Patients with Left-Sided RAS/BRAF Wild-Type Metastatic Colorectal Cancer: A Propensity Score-Based Analysis

Rossini, Daniele;Antoniotti, Carlotta;Borelli, Beatrice;Marmorino, Federica;Boccaccino, Alessandra;Masi, Gianluca;Falcone, Alfredo;Cremolini, Chiara
2020-01-01

Abstract

Doublets plus anti-epidermal growth factor receptors (EGFRs) are the preferred upfront option for patients with left-sided RAS/BRAF wild-type metastatic colorectal cancer (mCRC). Initial therapy with FOLFOXIRI-bevacizumab is superior to doublets plus bevacizumab independently from primary tumor sidedness and RAS/BRAF status. No randomized comparison between FOLFOXIRI-bevacizumab versus doublets plus anti-EGFRs is available in left-sided RAS/BRAF wild-type mCRC.
Pietrantonio, Filippo; Fucà, Giovanni; Rossini, Daniele; Schmoll, Hans-Joachim; Bendell, Johanna C; Morano, Federica; Antoniotti, Carlotta; Corallo, Salvatore; Borelli, Beatrice; Raimondi, Alessandra; Marmorino, Federica; Niger, Monica; Boccaccino, Alessandra; Masi, Gianluca; Lonardi, Sara; Boni, Luca; de Braud, Filippo; Di Bartolomeo, Maria; Falcone, Alfredo; Cremolini, Chiara
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/1071272
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