Marselli et al. find that human β cell dysfunction induced by metabolic stresses is persistent or transient. RNA sequencing and eQTL analysis identify key pathways underlying failure and recovery. Type 2 diabetes β cells have several functional and molecular alterations and share specific transcriptomic traits of β cells with irreversible or rescuable damage.
Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes
Marselli L.;Suleiman M.;Bugliani M.;Giusti L.;Boggi U.;De Simone P.;De Tata V.;De Luca C.;Tesi M.;Campani D.;Marchetti P.
2020-01-01
Abstract
Marselli et al. find that human β cell dysfunction induced by metabolic stresses is persistent or transient. RNA sequencing and eQTL analysis identify key pathways underlying failure and recovery. Type 2 diabetes β cells have several functional and molecular alterations and share specific transcriptomic traits of β cells with irreversible or rescuable damage.File in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
Persistent.pdf
accesso aperto
Tipologia:
Versione finale editoriale
Licenza:
Creative commons
Dimensione
4.11 MB
Formato
Adobe PDF
|
4.11 MB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
