Five new compounds, a flavonol glycoside (1), a megastigmane (2), two cyclohexylethanoids (3, 4) and a phenylethanoid derivative (5), together with fifteen known compounds (6-20) including flavonoid glycosides, cyclohexylethanoids, and phenolic compounds, have been isolated from Cornus sanguinea drupes. All the structures have been determined by 1D and 2D NMR spectroscopic analysis and mass spectrometry data. The antioxidant capability of the most representative isolated compounds was evaluated in the hydrogen peroxide (H2O2)-induced premature cellular senescence model of human dermal and gingival fibroblasts. Several derivatives counteracted the increase of ROS production in both cellular models. Among the most promising, compounds 8, 14, and 20 were able to counteract cell senescence decreasing the expression of p21 and p53. Furthermore, compound 14 decreased the expression of inflammatory cytokines (IL-6) in both cell models and counteracted the decrease of collagen expression induced by the H2O2 in dermal human fibroblasts. These data highlight the anti-aging properties of several isolated compounds from C. sanguinea drupes supporting its possible use in the cure of skin or periodontitis lesions.

Cornus sanguinea Fruits: a Source of Antioxidant and Antisenescence Compounds Acting on Aged Human Dermal and Gingival Fibroblasts

Anna Maria Iannuzzi
Co-primo
;
Chiara Giacomelli
Co-primo
;
Marinella De Leo
;
Lara Russo;Fabiano Camangi;Nunziatina De Tommasi;Alessandra Braca
;
Claudia Martini;Maria Letizia Trincavelli
Ultimo
2021-01-01

Abstract

Five new compounds, a flavonol glycoside (1), a megastigmane (2), two cyclohexylethanoids (3, 4) and a phenylethanoid derivative (5), together with fifteen known compounds (6-20) including flavonoid glycosides, cyclohexylethanoids, and phenolic compounds, have been isolated from Cornus sanguinea drupes. All the structures have been determined by 1D and 2D NMR spectroscopic analysis and mass spectrometry data. The antioxidant capability of the most representative isolated compounds was evaluated in the hydrogen peroxide (H2O2)-induced premature cellular senescence model of human dermal and gingival fibroblasts. Several derivatives counteracted the increase of ROS production in both cellular models. Among the most promising, compounds 8, 14, and 20 were able to counteract cell senescence decreasing the expression of p21 and p53. Furthermore, compound 14 decreased the expression of inflammatory cytokines (IL-6) in both cell models and counteracted the decrease of collagen expression induced by the H2O2 in dermal human fibroblasts. These data highlight the anti-aging properties of several isolated compounds from C. sanguinea drupes supporting its possible use in the cure of skin or periodontitis lesions.
2021
Iannuzzi, ANNA MARIA; Giacomelli, Chiara; DE LEO, Marinella; Russo, Lara; Camangi, Fabiano; De Tommasi, Nunziatina; Braca, Alessandra; Martini, Claudia; Trincavelli, MARIA LETIZIA
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/1106220
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 7
  • ???jsp.display-item.citation.isi??? 8
social impact