Tumors with homologous recombination (HR) deficiency (HRD) show high sensitivity to platinum salts and PARP-inhibitors in several malignancies. In colorectal cancer (CRC), the role of HRD alterations is mostly unknown.
Homologous Recombination Deficiency Alterations in Colorectal Cancer: Clinical, Molecular, and Prognostic Implications
Moretto, Roberto;Germani, Marco Maria;Conca, Veronica;Rossini, Daniele;Antoniotti, Carlotta;Aprile, Giuseppe;Masi, Gianluca;Falcone, Alfredo;Cremolini, Chiara
2021-01-01
Abstract
Tumors with homologous recombination (HR) deficiency (HRD) show high sensitivity to platinum salts and PARP-inhibitors in several malignancies. In colorectal cancer (CRC), the role of HRD alterations is mostly unknown.File in questo prodotto:
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