We evaluated the effect of DMTs on Covid-19 severity in patients with MS, with a pooled-analysis of two large cohorts from Italy and France. The association of baseline characteristics and DMTs with Covid-19 severity was assessed by multivariate ordinal-logistic models and pooled by a fixed-effect meta-analysis. 1066 patients with MS from Italy and 721 from France were included. In the multivariate model, anti-CD20 therapies were significantly associated (OR = 2.05, 95%CI = 1.39-3.02, p < 0.001) with Covid-19 severity, whereas interferon indicated a decreased risk (OR = 0.42, 95%CI = 0.18-0.99, p = 0.047). This pooled-analysis confirms an increased risk of severe Covid-19 in patients on anti-CD20 therapies and supports the protective role of interferon.

DMTs and Covid-19 severity in MS: a pooled analysis from Italy and France

Carmisciano L;Comi G;Arena S.;Borriello G.;Buccafusca M.;Bucciantini E.;Capuano R.;Carmisciano L.;Cocco E.;Cola G.;Comi G.;Correale C.;Cottone S.;Dattola V.;De Mitri P.;Gasperini C.;Grasso M. G.;Guerrieri S.;Iovino A.;Lapucci C.;Leva S.;Lo Re M.;Lucchini M.;Maimone D.;Milano E.;Mirabella M.;Montepietra S.;Pasquali L.;Perini P.;Petracca M.;Prosperini L.;Sabattini L.;Saraceno L.;Sartori A.;Sartori A.;Sbragia E.;Siciliano G.;Sinisi L.;Vianello M.;Virgilio E.;Vollaro S.;
2021-01-01

Abstract

We evaluated the effect of DMTs on Covid-19 severity in patients with MS, with a pooled-analysis of two large cohorts from Italy and France. The association of baseline characteristics and DMTs with Covid-19 severity was assessed by multivariate ordinal-logistic models and pooled by a fixed-effect meta-analysis. 1066 patients with MS from Italy and 721 from France were included. In the multivariate model, anti-CD20 therapies were significantly associated (OR = 2.05, 95%CI = 1.39-3.02, p < 0.001) with Covid-19 severity, whereas interferon indicated a decreased risk (OR = 0.42, 95%CI = 0.18-0.99, p = 0.047). This pooled-analysis confirms an increased risk of severe Covid-19 in patients on anti-CD20 therapies and supports the protective role of interferon.
2021
64., Sormani MP; Salvetti, M; Labauge, P; Schiavetti, I; Zephir, H; Carmisciano, L; Bensa, C; De Rossi, N; Pelletier, J; Cordioli, C; Vukusic, S; Moio...espandi
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/1110890
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 88
  • ???jsp.display-item.citation.isi??? 82
social impact