Sputum eosinophilia in Chronic Obstructive Pulmonary Disease (COPD) patients seems to be associated with a better response to inhaled corticosteroids (ICS). To verify if this feature could identify a specific subpopulation of COPD patients, we retrospectively compared functional and inflammatory parameters of 110 COPD patients according to the presence of sputum eosinophilia (>2%). Patient with eosinophilia were characterized by lower dyspnea score, lower functional impairment and lower ICS use, suggesting that airway eosinophilia may be associated to a lower COPD severity and some functional “asthma-like” characteristics, therefore explaining the better response to ICS in this subgroup of patients.

Are sputum eosinophils associated with a different phenotype in COPD patients? A retrospective study

Cianchetti S.;Celi A.;Paggiaro P.
2021-01-01

Abstract

Sputum eosinophilia in Chronic Obstructive Pulmonary Disease (COPD) patients seems to be associated with a better response to inhaled corticosteroids (ICS). To verify if this feature could identify a specific subpopulation of COPD patients, we retrospectively compared functional and inflammatory parameters of 110 COPD patients according to the presence of sputum eosinophilia (>2%). Patient with eosinophilia were characterized by lower dyspnea score, lower functional impairment and lower ICS use, suggesting that airway eosinophilia may be associated to a lower COPD severity and some functional “asthma-like” characteristics, therefore explaining the better response to ICS in this subgroup of patients.
2021
Bartoli, M. L.; Latorre, M.; Vagaggini, B.; Nieri, D.; Cianchetti, S.; Di Franco, A.; Celi, A.; Paggiaro, P.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/1121216
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