A variety of 2-alkynyl(benzo)imidazoles have been synthesized by dehydrogenative alkynylation of (benzo)imidazoles with terminal alkyne in NMP under air in the presence of Ag2CO3as the oxidant and Pd(OAc)2as the catalyst precursor. The data obtained in this study support a reaction mechanism involving a non-concerted metalation deprotonation (n-CMD) pathway.
Ligand-free Pd/Ag-mediated dehydrogenative alkynylation of imidazole derivatives
Bellina F.
Primo
Methodology
;Lessi M.Supervision
;Rosadoni E.Ultimo
Investigation
2021-01-01
Abstract
A variety of 2-alkynyl(benzo)imidazoles have been synthesized by dehydrogenative alkynylation of (benzo)imidazoles with terminal alkyne in NMP under air in the presence of Ag2CO3as the oxidant and Pd(OAc)2as the catalyst precursor. The data obtained in this study support a reaction mechanism involving a non-concerted metalation deprotonation (n-CMD) pathway.File in questo prodotto:
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2021 Bellina RSCAdvances Alkynylation def.pdf
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