Sydenham's chorea (SC) is a post-streptococcal autoimmune disorder of the central nervous system, and it is a major criterium for the diagnosis of acute rheumatic fever (ARF). SC typically improves in 12-15 weeks, but patients can be affected for years by persistence and recurrencies of both neurological and neuropsychiatric symptoms. We enrolled 48 patients with a previous diagnosis of ARF, with or without SC, in a national multicenter prospective study, to evaluate the presence of neuropsychiatric symptoms several years after SC's onset. Our population was divided in a SC group (n = 21), consisting of patients who had SC, and a nSC group (n = 27), consisting of patients who had ARF without SC. Both groups were evaluated by the administration of 8 different neuropsychiatric tests. The Work and Social Adjustment Scale (WSAS) showed significantly (p = 0.021) higher alterations in the SC group than in the nSC group. Furthermore, 60.4% (n = 29) of the overall population experienced neuropsychiatric symptoms other than choreic movements at diagnosis and this finding was significantly more common (p = 0.00) in SC patients (95.2%) than in nSC patients (33.3%). The other neuropsychiatric tests also produced significant results, indicating that SC can exert a strong psychopathological impact on patients even years after its onset.

Psychopathological Impact in Patients with History of Rheumatic Fever with or without Sydenham's Chorea: A Multicenter Prospective Study

Santangelo, Andrea;Battini, Roberta
;
Mosca, Marta;Baldini, Chiara;Peroni, Diego
;
Carmassi, Claudia
2022-01-01

Abstract

Sydenham's chorea (SC) is a post-streptococcal autoimmune disorder of the central nervous system, and it is a major criterium for the diagnosis of acute rheumatic fever (ARF). SC typically improves in 12-15 weeks, but patients can be affected for years by persistence and recurrencies of both neurological and neuropsychiatric symptoms. We enrolled 48 patients with a previous diagnosis of ARF, with or without SC, in a national multicenter prospective study, to evaluate the presence of neuropsychiatric symptoms several years after SC's onset. Our population was divided in a SC group (n = 21), consisting of patients who had SC, and a nSC group (n = 27), consisting of patients who had ARF without SC. Both groups were evaluated by the administration of 8 different neuropsychiatric tests. The Work and Social Adjustment Scale (WSAS) showed significantly (p = 0.021) higher alterations in the SC group than in the nSC group. Furthermore, 60.4% (n = 29) of the overall population experienced neuropsychiatric symptoms other than choreic movements at diagnosis and this finding was significantly more common (p = 0.00) in SC patients (95.2%) than in nSC patients (33.3%). The other neuropsychiatric tests also produced significant results, indicating that SC can exert a strong psychopathological impact on patients even years after its onset.
2022
Orsini, Alessandro; Foiadelli, Thomas; Sica, Attilio; Santangelo, Andrea; Carli, Niccolò; Bonuccelli, Alice; Consolini, Rita; D'Elios, Sofia; Loddo, Nicolò; Verrotti, Alberto; Di Cara, Giuseppe; Marra, Chiara; Califano, Maria; Fetta, Anna; Fabi, Marianna; Bergamoni, Stefania; Vignoli, Aglaia; Battini, Roberta; Mosca, Marta; Baldini, Chiara; Assanta, Nadia; Marchese, Pietro; Simonini, Gabriele; Marrani, Edoardo; Operto, Francesca Felicia; Pastorino, Grazia Maria Giovanna; Savasta, Salvatore; Santangelo, Giuseppe; Pedrinelli, Virginia; Massimetti, Gabriele; Dell'Osso, Liliana; Peroni, Diego; Cordelli, Duccio Maria; Corsi, Martina; Carmassi, Claudia
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/1158386
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