Background and purpose: Clinical outcomes of multiple sclerosis (MS) patients affected by coronavirus disease 2019 (COVID-19) have been thoroughly investigated, but a further analysis on main signs and symptoms and their risk factors still needs attention. The objective of this study was to group together and describe based on similarity the most common signs and symptoms of COVID-19 in MS patients and identify all factors associated with their manifestation. Method: Logistic and linear regression models were run to recognize factors associated with each pooled group of symptoms and their total number. Results: From March 2020 to November 2021, data were collected from 1354 MS patients with confirmed infection of COVID-19. Ageusia and anosmia was less frequent in older people (odds ratio [OR] 0.98; p = 0.005) and more in smoker patients (OR 1.39; p = 0.049). Smoke was also associated with an incremental number of symptoms (OR 1.24; p = 0.031), substance abuse (drugs or alcohol), conjunctivitis and rash (OR 5.20; p = 0.042) and the presence of at least one comorbidity with shortness of breath, tachycardia or chest pain (OR 1.24; p = 0.008). Some disease-modifying therapies were associated with greater frequencies of certain COVID-19 symptoms (association between anti-CD20 therapies and increment in the number of concomitant symptoms: OR 1.29; p = 0.05). Differences in frequencies between the three waves were found for flu-like symptoms (G1, p = 0.024), joint or muscle pain (G2, p = 0.013) and ageusia and anosmia (G5, p < 0.001). All cases should be referred to variants up to Delta. Conclusion: Several factors along with the choice of specific therapeutic approaches might have a different impact on the occurrence of some COVID-19 symptoms.

Signs and symptoms of COVID-19 in patients with multiple sclerosis

Carmisciano L;Cocco E;Livia Pasquali;Gabriele Siciliano;
2022-01-01

Abstract

Background and purpose: Clinical outcomes of multiple sclerosis (MS) patients affected by coronavirus disease 2019 (COVID-19) have been thoroughly investigated, but a further analysis on main signs and symptoms and their risk factors still needs attention. The objective of this study was to group together and describe based on similarity the most common signs and symptoms of COVID-19 in MS patients and identify all factors associated with their manifestation. Method: Logistic and linear regression models were run to recognize factors associated with each pooled group of symptoms and their total number. Results: From March 2020 to November 2021, data were collected from 1354 MS patients with confirmed infection of COVID-19. Ageusia and anosmia was less frequent in older people (odds ratio [OR] 0.98; p = 0.005) and more in smoker patients (OR 1.39; p = 0.049). Smoke was also associated with an incremental number of symptoms (OR 1.24; p = 0.031), substance abuse (drugs or alcohol), conjunctivitis and rash (OR 5.20; p = 0.042) and the presence of at least one comorbidity with shortness of breath, tachycardia or chest pain (OR 1.24; p = 0.008). Some disease-modifying therapies were associated with greater frequencies of certain COVID-19 symptoms (association between anti-CD20 therapies and increment in the number of concomitant symptoms: OR 1.29; p = 0.05). Differences in frequencies between the three waves were found for flu-like symptoms (G1, p = 0.024), joint or muscle pain (G2, p = 0.013) and ageusia and anosmia (G5, p < 0.001). All cases should be referred to variants up to Delta. Conclusion: Several factors along with the choice of specific therapeutic approaches might have a different impact on the occurrence of some COVID-19 symptoms.
2022
Schiavetti, I; Carmisciano, L; Ponzano, M; Cordioli, C; Cocco, E; Marfia, Ga; Inglese, M; Filippi, M; Radaelli, M; Bergamaschi, R; Immovilli, P; Capobianco, M; De Rossi, N; Brichetto, G; Scandellari, C; Cavalla, P; Pesci, I; Confalonieri, P; Perini, P; Trojano, M; Lanzillo, R; Tedeschi, G; Comi, G; Battaglia, Ma; Patti, F; Salvetti, M; Sormani MP Gianmarco Abbadessa, ; Umberto, Aguglia; Lia, Allegorico; Beatrice Maria Rossi Allegri, ; Anastasia, Alteno; Maria Pia Amato, ; Pietro, Annovazzi; Carlo, Antozzi; Lucia, Appendino; Sebastiano, Arena; Viola, Baione; Roberto, Balgera; Valeria, Barcella; Damiano, Baroncini; Caterina, Barrilà; Alessandra, Bellacosa; Gianmarco, Bellucci; Valeria, Bergamaschi; Daiana, Bezzini; Beatrice, Biolzi; Alvino, Bisecco; Simona, Bonavita; Giovanna, Borriello; Chiara, Bosa; Antonio, Bosco; Francesca, Bovis; Marco, Bozzali; Laura, Brambilla; Vincenzo Brescia Morra, ; Maria, Buccafusca; Elisabetta, Bucciantini; Sebastiano, Bucello; Maria Chiara Buscarinu, ; Maria Paola Cabboi, ; Massimiliano, Calabrese; Francesca, Calabria; Francesca, Caleri; Federico, Camilli; Luisa Maria Caniatti, ; Roberto, Cantello; Ruggero, Capra; Rocco, Capuano; Patrizia, Carta; Maria Grazia Celani, ; Maria, Cellerino; Raffaella, Cerqua; Clara, Chisari; Raffaella, Clerici; Marinella, Clerico; Gaia, Cola; Antonella, Conte; Marta Zaffira Conti, ; Christian, Cordano; Susanna, Cordera; Francesco, Corea; Claudio, Correale; Salvatore, Cottone; Francesco, Crescenzo; Erica, Curti; Alessandro, D'Ambrosio; Emanuele, D'Amico; Maura Chiara Danni, ; Alessia, D'Arma; Vincenzo, Dattola; Stefano de Biase, ; Giovanna De Luca, ; Stefania Federica De Mercanti, ; Paolo De Mitri, ; Nicola De Stefano, ; Fabio Maria Della Cava, ; Marco Della Cava, ; Sonia Di Lemme, ; Mario di Napoli, ; Alessia Di Sapio, ; Renato, Docimo; Anna, Dutto; Luana, Evangelista; Salvatore, Fanara; Roberta, Fantozzi; Diana, Ferraro; Maria Teresa Ferrò, ; Cristina, Fioretti; Mario, Fratta; Jessica, Frau; Marzia, Fronza; Roberto, Furlan; Alberto, Gajofatto; Antonio, Gallo; Paolo, Gallo; Claudio, Gasperini; Anna, Ghazaryan; Bruno, Giometto; Francesca, Gobbin; Flora, Govone; Franco, Granella; Erica, Grange; Maria Grazia Grasso, ; Luigi M, E Grimaldi; Angelica, Guareschi; Clara, Guaschino; Simone, Guerrieri; Donata, Guidetti; Ina Barbara Juergenson, ; Pietro, Iaffaldano; Antonio, Ianniello; Luigi, Iasevoli; Daniele, Imperiale; Maria Teresa Infante, ; Rosa, Iodice; Aniello, Iovino; Giovanna, Konrad; Doriana, Landi; Caterina, Lapucci; Luigi, Lavorgna; Maria Rita L'Episcopo, ; Serena, Leva; Giuseppe, Liberatore; Marianna Lo Re, ; Marco, Longoni; Leonardo, Lopiano; Lorena, Lorefice; Matteo, Lucchini; Giacomo, Lus; Davide, Maimone; Maria, Malentacchi; Giulia, Mallucci; Simona, Malucchi; Chiara Rosa Mancinelli, ; Luca, Mancinelli; Paolo, Manganotti; Giorgia Teresa Maniscalco, ; Vittorio, Mantero; Sabrina, Marangoni; Damiano, Marastoni; Fabiana, Marinelli; Alessandro, Marti; Filippo Boneschi Martinelli, ; Zoli Federco Masserano, ; Francesca, Matta; Laura, Mendozzi; Giuseppe, Meucci; Silvia, Miante; Giuseppina, Miele; Eva, Milano; Massimiliano, Mirabella; Rosanna, Missione; Marcello, Moccia; Lucia, Moiola; Sara, Montepietra; Margherita, Montibragadin; Federico, Montini; Roberta, Motta; Raffaele, Nardone; Carolina Gabri Nicoletti, ; Eduardo, Nobile-Orazio; Agostino, Nozzolillo; Marco, Onofrj; Riccardo, Orlandi; Anna, Palmieri; Damiano, Paolicelli; Pasquali, Livia; Luisa, Pastò; Elisabetta, Pedrazzoli; Maria, Petracca; Alfredo, Petrone; Carlo, Piantadosi; Anna, M Pietroboni; Federica, Pinardi; Emilio, Portaccio; Mattia, Pozzato; Carlo, Pozzilli; Luca, Prosperini; Alessandra, Protti; Paolo, Ragonese; Sarah, Rasia; Sabrina, Realmuto; Anna, Repice; Eleonora, Rigoni; Maria Teresa Rilla, ; Francesca, Rinaldi; Calogero Marcello Romano, ; Marco, Ronzoni; Marco, Rovaris; Francesca, Ruscica; Loredana, Sabattini; Giuseppe, Salemi; Lorenzo, Saraceno; Alessia, Sartori; Arianna, Sartori; Elvira, Sbragia; Giuditta Ilaria Scarano, ; Valentina, Scarano; Maria, Sessa; Caterina, Sgarito; Grazia, Sibilia; Siciliano, Gabriele; Alessio, Signori; Elisabetta, Signoriello; Leonardo, Sinisi; Francesca, Sireci; Patrizia, Sola; Claudio, Solaro; Stefano, Sotgiu; Maddalena, Sparaco; Maria Laura Stromillo, ; Silvia, Strumia; Emanuela Laura Susani, ; Giulietta, Tabiadon; Francesco, Teatini; Valentina, Tomassini; Simone, Tonietti; Valentina, Torri; Carla, Tortorella; Simona, Toscano; Rocco, Totaro; Maria, Trotta; Gabriella, Turano; Monica, Ulivelli; Manzo, Valentino; Giovanna, Vaula; Domizia, Vecchio; Marco, Vercellino; Elena Pinuccia Verrengia, ; Marika, Vianello; Eleonora, Virgilio; Francesca, Vitetta; Stefano, Vollaro; Mauro, Zaffaroni; Mauro, Zampolini; Ignazio Roberto Zarbo, ; Antonio, Zito; Luigi, Zuliani
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/1160663
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