Abstract Objective A high triglyceride (TG) to high-density lipoprotein cholesterol (HDL) ratio (TG/HDL) predicts atherosclerosis and cardiovascular events. This study examined whether a proatherogenic distribution of plasma lipoprotein subclasses is associated with a high TG/HDL ratio in youths with obesity. Methods Lipoprotein particle concentration and size were measured by proton nuclear magnetic resonance in a multiethnic cohort of 592 adolescents with overweight/obesity (age 13?±?3?years, 58% females, BMI z score 2.1?±?0.8) who were phenotyped with a 3-hour oral glucose tolerance test and abdominal magnetic resonance imaging. Results The highest TG/HDL quartile showed a higher particle concentration of very low-density lipoprotein (VLDL; +178%, p?
Proatherogenic changes in lipoprotein particles associated with a high triglyceride to high-density lipoprotein cholesterol ratio in youths
Chiriaco, Martina;Nesti, Lorenzo;Natali, Andrea;Tricò, Domenico
2023-01-01
Abstract
Abstract Objective A high triglyceride (TG) to high-density lipoprotein cholesterol (HDL) ratio (TG/HDL) predicts atherosclerosis and cardiovascular events. This study examined whether a proatherogenic distribution of plasma lipoprotein subclasses is associated with a high TG/HDL ratio in youths with obesity. Methods Lipoprotein particle concentration and size were measured by proton nuclear magnetic resonance in a multiethnic cohort of 592 adolescents with overweight/obesity (age 13?±?3?years, 58% females, BMI z score 2.1?±?0.8) who were phenotyped with a 3-hour oral glucose tolerance test and abdominal magnetic resonance imaging. Results The highest TG/HDL quartile showed a higher particle concentration of very low-density lipoprotein (VLDL; +178%, p?I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
