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EnglishA detailed understanding of the molecular process involved in the proliferation of pancreatic precursor cells would provide key elements for developing new therapeutic strategies to cure type 1 diabetes. In the present study we investigated the potential involvement of hedgehog signaling in proliferating human pancreatic islet-derived mesenchymal (hPIDM) cells, a population of cells that can be successfully expanded and induced to differentiate into an insulin-secreting phenotype. Here we report that in these precursor cells a hedgehog signaling pathway is activated, as shown by Gli1 expression, and that a dose-dependent inhibition of such a pathway by cyclopamine results in a significant reduction of cell proliferation.
| Autori interni: | |
| Autori: | Gallo, R; Grieco, Fa; Marselli, Lorella; Ferretti, E; Gulino, A; Marchetti, Piero; Dotta, F. |
| Titolo: | Hedgehog signaling during expansion of human pancreatic islet-derived precursors |
| Anno del prodotto: | 2008 |
| Digital Object Identifier (DOI): | 10.1196/annals.1447.024 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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