The ADAMs belong to the Adamalysin family of zinc-dependent metalloproteinases. Some ADAMs, as membrane-bound enzymes, are responsible for the ectodomain shedding of transmembrane proteins such as growth factors, the tumor necrosis factor, cytokines and their receptors, signaling molecules, adhesion proteins, and stress molecules involved in immunity. These activities contribute to regulate several physiological and pathological processes including inflammation, cancer, and neurodegenerative diseases. For these reasons, some ADAMs are currently investigated as drug targets to develop new alternative therapies in many fields of medicine. In this chapter, we focus our attention on the most studied ADAMs, that is, ADAM8, ADAM10, and ADAM17 and describe the most innovative ADAM inhibitors developed in the past 10years, taking in consideration synthetic small molecules, natural compounds, and peptide-based inhibitors.
A disintegrin and metalloproteinases (ADAMs) and tumor necrosis factor-alpha-converting enzyme (TACE)
Doretta CuffaroPrimo
;Matteo Calligaris;Elisa NutiPenultimo
;Armando Rossello a
Ultimo
2023-01-01
Abstract
The ADAMs belong to the Adamalysin family of zinc-dependent metalloproteinases. Some ADAMs, as membrane-bound enzymes, are responsible for the ectodomain shedding of transmembrane proteins such as growth factors, the tumor necrosis factor, cytokines and their receptors, signaling molecules, adhesion proteins, and stress molecules involved in immunity. These activities contribute to regulate several physiological and pathological processes including inflammation, cancer, and neurodegenerative diseases. For these reasons, some ADAMs are currently investigated as drug targets to develop new alternative therapies in many fields of medicine. In this chapter, we focus our attention on the most studied ADAMs, that is, ADAM8, ADAM10, and ADAM17 and describe the most innovative ADAM inhibitors developed in the past 10years, taking in consideration synthetic small molecules, natural compounds, and peptide-based inhibitors.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
