Purpose: Clinical evidence suggests an association between comorbidities and outcome in patients with glioblastoma (GBM). We hypothesised that the internal carotid artery (ICA) calcium score could represent a promising prognostic biomarker in a competing risk analysis in patients diagnosed with GBM. Methods: We validated the use of the ICA calcium score as a surrogate marker of the coronary calcium score in 32 patients with lung cancer. Subsequently, we assessed the impact of the ICA calcium score on overall survival in GBM patients treated with radio-chemotherapy. Results: We analysed 50 GBM patients. At the univariate analysis, methyl-guanine-methyltransferase gene (MGMT) promoter methylation (p = 0.048), gross total tumour resection (p = 0.017), and calcium score (p = 0.011) were significant prognostic predictors in patients with GBM. These three variables also maintained statistical significance in the multivariate analysis. Conclusions: the ICA calcium score could be a promising prognostic biomarker in GBM patients.

Glioblastoma and Internal Carotid Artery Calcium Score: A Possible Novel Prognostic Partnership?

Pasqualetti Francesco
Co-primo
;
Gabelloni Michela
Co-primo
;
Faggioni Lorenzo;Aquaro Giovanni Donato;De Vietro Fabrizio;Mendola Vincenzo;Spina Nicola;Frey Jessica;Montemurro Nicola;Cantarella Martina;Gadducci Giovanni;Giannini Noemi;Valenti Silvia;Morganti Riccardo;Vergaro Giuseppe;Cosottini Mirco;Naccarato Antonio Giuseppe;Lombardi Giuseppe;Bocci Guido
Co-primo
;
Neri Emanuele;Paiar Fabiola
2024-01-01

Abstract

Purpose: Clinical evidence suggests an association between comorbidities and outcome in patients with glioblastoma (GBM). We hypothesised that the internal carotid artery (ICA) calcium score could represent a promising prognostic biomarker in a competing risk analysis in patients diagnosed with GBM. Methods: We validated the use of the ICA calcium score as a surrogate marker of the coronary calcium score in 32 patients with lung cancer. Subsequently, we assessed the impact of the ICA calcium score on overall survival in GBM patients treated with radio-chemotherapy. Results: We analysed 50 GBM patients. At the univariate analysis, methyl-guanine-methyltransferase gene (MGMT) promoter methylation (p = 0.048), gross total tumour resection (p = 0.017), and calcium score (p = 0.011) were significant prognostic predictors in patients with GBM. These three variables also maintained statistical significance in the multivariate analysis. Conclusions: the ICA calcium score could be a promising prognostic biomarker in GBM patients.
2024
Pasqualetti, Francesco; Gabelloni, Michela; Faggioni, Lorenzo; Aquaro, GIOVANNI DONATO; DE VIETRO, Fabrizio; Mendola, Vincenzo; Spina, Nicola; Frey, J...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/1226787
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