A selective direct arylation of the different Csp2-H bonds of imidazo[2,1-b]thiazole with (hetero) aryl halides can be achieved simply by switching from a palladium catalyst system to the use of stoichiometric amounts of copper. The observed selectivity, also rationalized by DFT calculations, can be explained by a change in the mechanistic pathways between electrophilic palladation and base-promoted C−H metalation.
Transition Metal-Driven Selectivity in Direct C−H Arylation of Imidazo[2,1-b]Thiazole
Del Vecchio A.Writing – Original Draft Preparation
;Ballerini L.Investigation
;Lipparini F.Formal Analysis
;Lessi M.Investigation
;Bellina F.
Supervision
2024-01-01
Abstract
A selective direct arylation of the different Csp2-H bonds of imidazo[2,1-b]thiazole with (hetero) aryl halides can be achieved simply by switching from a palladium catalyst system to the use of stoichiometric amounts of copper. The observed selectivity, also rationalized by DFT calculations, can be explained by a change in the mechanistic pathways between electrophilic palladation and base-promoted C−H metalation.File in questo prodotto:
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