We describe a computational platform to predict atherosclerotic plaque onset and growth in carotids. It integrates in-vivo data, Computational Fluid Dynamics (CFD) simulations and a model for plaque growth linearly correlating the plaque progression with low values of time-averaged Wall Shear Stresses (WSS). We show that steady CFD simulations give the same averaged-WSS values as unsteady simulations. Therefore, the model for plaque growth can be coupled with steady simulations, reducing the computational costs. Finally, by comparing the numerical predictions with the in-vivo data, we show that a modification must be introduced in the plaque growth model to obtain acceptable results.

TOWARDS THE PREDICTION OF PLAQUE ONSET AND GROWTH IN CAROTID ARTERIES

Singh J.
Primo
;
Capellini K.;Fanni B. M.;Mariotti A.;Salvetti M. V.;Celi S.
2024-01-01

Abstract

We describe a computational platform to predict atherosclerotic plaque onset and growth in carotids. It integrates in-vivo data, Computational Fluid Dynamics (CFD) simulations and a model for plaque growth linearly correlating the plaque progression with low values of time-averaged Wall Shear Stresses (WSS). We show that steady CFD simulations give the same averaged-WSS values as unsteady simulations. Therefore, the model for plaque growth can be coupled with steady simulations, reducing the computational costs. Finally, by comparing the numerical predictions with the in-vivo data, we show that a modification must be introduced in the plaque growth model to obtain acceptable results.
2024
Singh, J.; Capellini, K.; Fanni, B. M.; Mariotti, A.; Salvetti, M. V.; Celi, S.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/1272791
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