Deep Eutectic Solvents (DESs) are emerging in the recent literature as promising environmentally friendly liquids in different topics, finding fruitful applications as substitutes to common volatile organic solvents. In this work a study of cluster formation of water-based DESs in water dilutions is presented. The three analysed mixtures are: glycolic acid/water (GA/H2O); betaine/water (TMG/H2O), choline chloride/water (ChCl/H2O). Ionic conductivity, viscosity, ultrasound spectroscopy and NMR techniques showed the presence of aggregates of aquoDESs in water dilutions. These aggregates are present in the solutions until values about 50 % w/w of added water, showing the presence of water-in-water structured systems. Moreover, taking into account the convenient disposal as water dilution of a DES, the cytotoxicity of these dilutions was evaluated on Caco2 model cells, showing the effect to be related only to the non-water components of these liquids. The water dilutions of water-based DESs have a great relevance for their applications, because their physical properties can be modulated as needed preserving their DESs’ identities.
Cluster aggregation of water-based deep eutectic solvents in water and evaluation of their cytotoxicity
Gianluca Ciancaleoni;
2024-01-01
Abstract
Deep Eutectic Solvents (DESs) are emerging in the recent literature as promising environmentally friendly liquids in different topics, finding fruitful applications as substitutes to common volatile organic solvents. In this work a study of cluster formation of water-based DESs in water dilutions is presented. The three analysed mixtures are: glycolic acid/water (GA/H2O); betaine/water (TMG/H2O), choline chloride/water (ChCl/H2O). Ionic conductivity, viscosity, ultrasound spectroscopy and NMR techniques showed the presence of aggregates of aquoDESs in water dilutions. These aggregates are present in the solutions until values about 50 % w/w of added water, showing the presence of water-in-water structured systems. Moreover, taking into account the convenient disposal as water dilution of a DES, the cytotoxicity of these dilutions was evaluated on Caco2 model cells, showing the effect to be related only to the non-water components of these liquids. The water dilutions of water-based DESs have a great relevance for their applications, because their physical properties can be modulated as needed preserving their DESs’ identities.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.