From the n-butanol ext. of the aerial parts of Exellodendron coriaceum (Benth.) Prance the flavonoids quercetin-3-O-β-D-galactopyranoside (1), quercetin-3-O-α-L-arabinopyranoside (2), quercetin-3-O-α-L-rhamnopyranosyl-(1→2)-α-L- rhamnopyranoside (3), and quercetin-3-O-α-L-rhamnopyranosyl-(1→6)-β-D- galactopyranoside (4) were isolated. Addnl. from this ext. 3 flavonoids were isolated and partially characterized as quercetin glycosides. All these compds. were tested for their hypoglycemic activity using the glucose-6-phosphatase microsomal hepatic system. The flavonoids inhibited the activity of the enzyme when intact microsomes were used, the highest percentage of inhibition being 65%. To the best of our knowledge, this is the 1st report of chem. and biol. activity of E. coriaceum.

Effect of flavonoids from Exellodendron coriaceum (Chrysobalanaceae) on glucose-6-phosphatase

BRACA, ALESSANDRA;DE LEO, MARINELLA;
2009

Abstract

From the n-butanol ext. of the aerial parts of Exellodendron coriaceum (Benth.) Prance the flavonoids quercetin-3-O-β-D-galactopyranoside (1), quercetin-3-O-α-L-arabinopyranoside (2), quercetin-3-O-α-L-rhamnopyranosyl-(1→2)-α-L- rhamnopyranoside (3), and quercetin-3-O-α-L-rhamnopyranosyl-(1→6)-β-D- galactopyranoside (4) were isolated. Addnl. from this ext. 3 flavonoids were isolated and partially characterized as quercetin glycosides. All these compds. were tested for their hypoglycemic activity using the glucose-6-phosphatase microsomal hepatic system. The flavonoids inhibited the activity of the enzyme when intact microsomes were used, the highest percentage of inhibition being 65%. To the best of our knowledge, this is the 1st report of chem. and biol. activity of E. coriaceum.
Carrasco, D.; Méndez, J.; Braca, Alessandra; DE LEO, Marinella; GONZÁLEZ MUJICA, F.; Duque, S.
File in questo prodotto:
File Dimensione Formato  
EC.pdf

solo utenti autorizzati

Tipologia: Versione finale editoriale
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 557.78 kB
Formato Adobe PDF
557.78 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/134964
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 3
  • ???jsp.display-item.citation.isi??? 2
social impact