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EnglishThe 3-aminoxy-(E)-2-methoxyiminopropionyl penicillins 13 and cephalosporins 14 and 15 were synthesized and assayed for their antimicrobial activity on Gram-positive and Gram-negative bacteria whether producers of β-lactamases or otherwise. Compounds 13, 14, and 15 exhibited an activity which was generally lower than that of the corresponding phenylacetyl derivative: penicillin G (4), cephaloram (5), and phenylacetamidodesacetoxycephalosporanic acid (6). Furthermore, the comparison of the minimum inhibitory concentration values of some of the new 2-methoxyimino 3-aminoxypropionyl derivatives 13-15 with those of the corresponding ones 1-3 lacking the 2-methoxyimino substituent showed that the introduction of the 2-methoxyimino group of E configuration on the aminoxypropionamido side chain of 1-3 gives compounds (13-15) which do not generally possess better antimicrobial properties.
| Autori interni: | ||
| Autori: | A. BALSAMO; B.MACCHIA; A.MARTINELLI; E.ORLANDINI; F.MACCHIA; G. BROCCALI; P. DOMIANO; ROSSELLO A | |
| Titolo: | Synthesis and antimicrobial properties of substituted 3-aminoxy-(E)-2-methoxyiminopropionyl penicillins and cephalosporins | |
| Anno del prodotto: | 1990 | |
| Digital Object Identifier (DOI): | 10.1016/0223-5234(90)90205-H | |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
File in questo prodotto:
http://hdl.handle.net/11568/13941
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