The genetic structure of the population of Ferrara Province in the Po delta in Italy was investigated using χ 2 analysis, kinship analysis, analysis of correspondences, and geographical mapping of principal components of gene frequencies. χ 2 Analysis tests for Hardy-Weinberg equilibrium and for heterogeneity of gene and phenotype frequencies; kinship analysis tests for association between indicators of genetic and geographic proximity; analysis of correspondences relates localities and genetic systems in an eigenvectorial space; and geographic mapping displays the principal components of gene frequencies in the real space. In 1,364 adults in 26 residential units, seven presumably neutral isoenzyme systems were typed; ACP 1, ESD, GLO I, GPT, PGD, PGM 1 and PGP. It was found that average kinship for these neutral systems is correlated with geographic distance in this small area, but not as strongly as kinship for beta-thalassemia. A north-south gradient was observed for ESD. Analysis of correspondences indicated GPT, PGM 1, and GLO I as the systems contributing most to differentiaton within the province. The maps obtained from principal components of gene frequencies were consistent with the migrational history of the area.
|Autori:||Beretta M; Mazzetti P; Mamolini E; Gavina R; Barale R; Vullo C; Ravani A; Franze A; Sapigni T; Soracco E; et a|
|Titolo:||Genetic structure of the human population in the Po delta|
|Anno del prodotto:||1989|
|Appare nelle tipologie:||1.1 Articolo in rivista|