The EU project Nutra-Snack established an integrated scien- tific and technological framework to introduce conventional and new biotechnologies into the nutraceutical industry. The purpose was to promote novel ready-to-eat snacks enriched with natural antioxidant/radical-scavenging compounds. En- hancement of valuable compounds production in plant cells and in vitro cultures were achieved by different elicitation strategies, and exhaustive metabolites profiling obtained by high-resolution analytical techniques. Finally, innovative enzyme-based biosensors were developed for food products functional activity and safety properties assessment. This review provides an overview of the technologies selected, in- tegrated and tested in NUTRA-SNACK and recent literature strengthening integrated approaches in modern food process manufacturing