Polygenic type 2 diabetes mellitus (T2DM) is a multi-factorial disease due to the interplay between genes and the environment. Over the years, several genes/loci have been associated with this type of diabetes, with the majority of them being related to β cell dysfunction. In this review, the available information on how polymorphisms in T2DM-associated genes/loci do directly affect the properties of human islet cells are presented and discussed, including some clinical implications and the role of epigenetic mechanisms.
|Autori:||Marchetti, Piero; Syed, Farooq; Suleiman, Mara; Bugliani, Marco; Marselli, Lorella|
|Titolo:||From genotype to human ß cell phenotype and beyond|
|Anno del prodotto:||2012|
|Digital Object Identifier (DOI):||10.4161/islets.22282|
|Appare nelle tipologie:||1.1 Articolo in rivista|