Reversible and selective binding of a dynamically racemic europium(iii) complex to α 1-acid glycoprotein and α 1- antitrypsin is characterised by a significant change in the europium total emission spectral fingerprint and the switching on of a large circularly polarised luminescence (CPL) signal from the metal centre. Observation of an induced CD into the ligand chromophore in the presence of α 1- AGP allows a structure for the protein-bound complex to be postulated. A direct determination of elevated α 1-AGP levels in human serum was achieved by monitoring changes in the intensity ratio of Eu emission bands.

A chiral probe for the acute phase proteins alpha-1-acid glycoprotein and alpha-1-antitrypsin based on europium luminescence

DI BARI, LORENZO;
2012-01-01

Abstract

Reversible and selective binding of a dynamically racemic europium(iii) complex to α 1-acid glycoprotein and α 1- antitrypsin is characterised by a significant change in the europium total emission spectral fingerprint and the switching on of a large circularly polarised luminescence (CPL) signal from the metal centre. Observation of an induced CD into the ligand chromophore in the presence of α 1- AGP allows a structure for the protein-bound complex to be postulated. A direct determination of elevated α 1-AGP levels in human serum was achieved by monitoring changes in the intensity ratio of Eu emission bands.
Carr, R; DI BARI, Lorenzo; Lo Piano, S; Parker, D; Peacock, Rd; Sanderson, Jm
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/154041
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