BACKGROUND: The pathogenic role of oxidative stress in obstructive sleep apnea syndrome (OSAS) is still a matter of debate, with different studies obtaining contrasting results. METHODS: The aim of the present study was to evaluate three well-known markers of oxidative stress (advanced oxidation protein products [AOPP], ferric reducing antioxidant power [FRAP], and total glutathione [GSH]) in a cohort of 41 untreated patients with a new diagnosis of OSAS. RESULTS: We observed that OSAS patients showed increased protein oxidative damage and impaired antioxidant defenses. Patients with more severe OSAS had a lower total antioxidant capability. Preliminary data on a subgroup of patients (n=7) treated with CPAP show a significant increment of the FRAP values (P<0.005). CONCLUSIONS: Our findings indicate that such oxidative stress markers may be useful to detect and monitor redox imbalance in OSAS. Moreover, FRAP might be a new useful biomarker to monitor in vivo the oxidative response to CPAP therapy.

Oxidative stress biomarkers in patients with untreated obstructive sleep apnea syndrome.

MANCUSO, MICHELANGELO
Primo
;
BONANNI, ENRICA
Secondo
;
ORSUCCI, DANIELE;MAESTRI, MICHELANGELO;DI COSCIO, ELISA;SICILIANO, GABRIELE
Penultimo
;
MURRI, LUIGI
2012

Abstract

BACKGROUND: The pathogenic role of oxidative stress in obstructive sleep apnea syndrome (OSAS) is still a matter of debate, with different studies obtaining contrasting results. METHODS: The aim of the present study was to evaluate three well-known markers of oxidative stress (advanced oxidation protein products [AOPP], ferric reducing antioxidant power [FRAP], and total glutathione [GSH]) in a cohort of 41 untreated patients with a new diagnosis of OSAS. RESULTS: We observed that OSAS patients showed increased protein oxidative damage and impaired antioxidant defenses. Patients with more severe OSAS had a lower total antioxidant capability. Preliminary data on a subgroup of patients (n=7) treated with CPAP show a significant increment of the FRAP values (P<0.005). CONCLUSIONS: Our findings indicate that such oxidative stress markers may be useful to detect and monitor redox imbalance in OSAS. Moreover, FRAP might be a new useful biomarker to monitor in vivo the oxidative response to CPAP therapy.
Mancuso, Michelangelo; Bonanni, Enrica; Logerfo, A; Orsucci, Daniele; Maestri, Michelangelo; Chico, L; DI COSCIO, Elisa; Fabbrini, M; Siciliano, Gabriele; Murri, Luigi
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/173611
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