BACKGROUND: The pathogenic role of oxidative stress in obstructive sleep apnea syndrome (OSAS) is still a matter of debate, with different studies obtaining contrasting results. METHODS: The aim of the present study was to evaluate three well-known markers of oxidative stress (advanced oxidation protein products [AOPP], ferric reducing antioxidant power [FRAP], and total glutathione [GSH]) in a cohort of 41 untreated patients with a new diagnosis of OSAS. RESULTS: We observed that OSAS patients showed increased protein oxidative damage and impaired antioxidant defenses. Patients with more severe OSAS had a lower total antioxidant capability. Preliminary data on a subgroup of patients (n=7) treated with CPAP show a significant increment of the FRAP values (P<0.005). CONCLUSIONS: Our findings indicate that such oxidative stress markers may be useful to detect and monitor redox imbalance in OSAS. Moreover, FRAP might be a new useful biomarker to monitor in vivo the oxidative response to CPAP therapy.
|Autori:||Mancuso M; Bonanni E; Logerfo A; Orsucci D; Maestri M; Chico L; Dicoscio E; Fabbrini M; Siciliano G; Murri L|
|Titolo:||Oxidative stress biomarkers in patients with untreated obstructive sleep apnea syndrome.|
|Anno del prodotto:||2012|
|Digital Object Identifier (DOI):||10.1016/j.sleep.2011.10.030|
|Appare nelle tipologie:||1.1 Articolo in rivista|